Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 78202..78863 Replicon plasmid p1
Accession NZ_CP019949
Organism Methylocystis bryophila strain S285

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag B1812_RS21650 Protein ID WP_085773935.1
Coordinates 78202..78627 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag B1812_RS21655 Protein ID WP_085773936.1
Coordinates 78627..78863 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B1812_RS21620 73656..73994 - 339 WP_210190845.1 hypothetical protein -
B1812_RS21625 74114..74533 - 420 WP_085773930.1 type II toxin-antitoxin system MqsA family antitoxin -
B1812_RS21630 74536..74841 - 306 WP_085773931.1 type II toxin-antitoxin system MqsR family toxin -
B1812_RS21635 75134..75838 - 705 WP_085773932.1 SMC-Scp complex subunit ScpB -
B1812_RS21640 75845..76795 - 951 WP_158658929.1 DUF1403 family protein -
B1812_RS21645 77030..78163 + 1134 WP_085773934.1 tyrosine-type recombinase/integrase -
B1812_RS21650 78202..78627 - 426 WP_085773935.1 type II toxin-antitoxin system VapC family toxin Toxin
B1812_RS21655 78627..78863 - 237 WP_085773936.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
B1812_RS21660 79135..80469 - 1335 WP_085773937.1 replication initiation protein RepC -
B1812_RS21665 80688..81665 - 978 WP_102938232.1 plasmid partitioning protein RepB -
B1812_RS21670 81644..82867 - 1224 WP_085773938.1 plasmid partitioning protein RepA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..175021 175021


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-127)

Antitoxin

Antitoxin VapB-like

(2-75)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15259.30 Da        Isoelectric Point: 4.5070

>T73564 WP_085773935.1 NZ_CP019949:c78627-78202 [Methylocystis bryophila]
MFVDTSAIVAILCGEDDAAELAGRLASAERRFTSPVVRLEACMVLALKLDITPAQANALFEDFLDEAHVSITPINDKIGV
LAVACFESYGKGRHPARLNLGDCLSYACAKAYRSALLFKEDDFSQTDVETTSARARNDPQS

Download         Length: 426 bp

>T73564 NZ_CP019949:c78627-78202 [Methylocystis bryophila]
ATGTTCGTGGACACCTCCGCGATCGTAGCGATCCTCTGCGGCGAGGATGACGCTGCCGAGCTTGCGGGACGCCTCGCGTC
GGCGGAGCGGCGTTTTACGTCGCCGGTCGTCCGGCTGGAGGCGTGCATGGTGCTGGCGTTAAAGCTCGACATCACGCCGG
CGCAGGCAAACGCTCTGTTCGAGGATTTTCTCGACGAGGCGCATGTCTCGATCACGCCGATCAATGACAAGATTGGCGTT
CTCGCCGTCGCCTGCTTCGAGAGCTACGGCAAGGGACGGCATCCGGCGCGATTGAATCTCGGCGACTGCCTCTCCTATGC
GTGCGCCAAGGCCTACCGCTCGGCGCTACTGTTCAAGGAAGACGATTTTTCGCAAACAGACGTCGAAACGACGAGCGCGC
GGGCGCGAAACGACCCGCAAAGCTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8917.49 Da        Isoelectric Point: 10.8628

>AT73564 WP_085773936.1 NZ_CP019949:c78863-78627 [Methylocystis bryophila]
MLSIRDPRAAELAKLLAARRKTTMTEAIIVALENELKRERERVPLPERLARLAVKARKLAGPKGRDVPKEELDEFWGQ

Download         Length: 237 bp

>AT73564 NZ_CP019949:c78863-78627 [Methylocystis bryophila]
ATGCTCAGCATACGGGACCCGCGAGCGGCAGAGCTCGCAAAGCTGCTCGCCGCTCGGCGCAAAACCACGATGACCGAAGC
CATTATCGTGGCGTTGGAGAATGAGTTGAAACGGGAGCGCGAGCGGGTTCCGCTGCCCGAGCGACTTGCGCGCTTGGCCG
TAAAAGCTCGGAAGCTCGCCGGGCCAAAGGGCCGTGACGTCCCCAAGGAAGAACTCGACGAATTCTGGGGCCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References