Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3789802..3790433 Replicon chromosome
Accession NZ_CP019948
Organism Methylocystis bryophila strain S285

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag B1812_RS17975 Protein ID WP_085772819.1
Coordinates 3789802..3790200 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag B1812_RS17980 Protein ID WP_085773816.1
Coordinates 3790200..3790433 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B1812_RS17960 3785094..3786095 + 1002 WP_085772816.1 MoxR family ATPase -
B1812_RS17965 3786098..3787033 + 936 WP_085772817.1 DUF58 domain-containing protein -
B1812_RS17970 3787024..3789786 + 2763 WP_085772818.1 DUF4159 domain-containing protein -
B1812_RS17975 3789802..3790200 - 399 WP_085772819.1 type II toxin-antitoxin system VapC family toxin Toxin
B1812_RS17980 3790200..3790433 - 234 WP_085773816.1 antitoxin Antitoxin
B1812_RS17985 3790617..3793022 + 2406 WP_085772820.1 phosphoketolase family protein -
B1812_RS17990 3793167..3793757 + 591 WP_085772821.1 histidine phosphatase family protein -
B1812_RS17995 3793895..3794482 - 588 WP_085772822.1 hypothetical protein -
B1812_RS18000 3794539..3795288 - 750 WP_085772823.1 DUF3142 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14824.07 Da        Isoelectric Point: 7.2911

>T73563 WP_085772819.1 NZ_CP019948:c3790200-3789802 [Methylocystis bryophila]
MLNYMLDTNICIYVMKTYPPALRDKFNGLAEQLCISSITLGELHYGAEKSARRTENLKAIEQFVARLEVLPFAEKAAAHY
GQVRAELERAGTPCGPHDMQIGGHARSEGLIVVTNNFREFARMPGVRVENWV

Download         Length: 399 bp

>T73563 NZ_CP019948:c3790200-3789802 [Methylocystis bryophila]
ATGCTCAACTATATGCTGGACACAAACATCTGCATTTACGTGATGAAGACTTATCCACCCGCCCTCCGCGACAAATTCAA
TGGGTTGGCGGAGCAGCTTTGCATATCGAGCATCACGCTGGGCGAACTGCATTATGGCGCGGAGAAGTCGGCGCGACGAA
CCGAGAACTTAAAGGCAATCGAGCAATTCGTGGCGCGGCTGGAAGTGCTTCCGTTCGCGGAGAAGGCTGCCGCGCATTAC
GGGCAAGTCCGAGCCGAACTGGAGCGGGCCGGAACGCCTTGTGGTCCGCATGACATGCAGATCGGCGGTCATGCCCGCAG
CGAGGGGCTCATCGTCGTCACCAACAATTTTCGAGAATTCGCAAGAATGCCGGGCGTGAGAGTGGAGAATTGGGTGTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8912.17 Da        Isoelectric Point: 8.9533

>AT73563 WP_085773816.1 NZ_CP019948:c3790433-3790200 [Methylocystis bryophila]
MTRSTVFTSNRSQAVRLPKAVAFPEEVHHVDILKIGRTRVIAPQGKRWDDLFLHGPRVTDDFMVEREQPPAETREPF

Download         Length: 234 bp

>AT73563 NZ_CP019948:c3790433-3790200 [Methylocystis bryophila]
ATGACCCGTTCGACCGTCTTCACCAGCAATCGCAGCCAGGCCGTTCGCCTTCCAAAGGCCGTCGCCTTCCCGGAGGAGGT
CCATCACGTCGATATCCTCAAGATCGGCCGCACTCGCGTGATCGCGCCTCAGGGCAAAAGGTGGGACGACCTTTTCTTGC
ACGGGCCGCGCGTCACTGACGATTTCATGGTCGAGCGAGAGCAACCGCCCGCAGAGACTCGCGAGCCTTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References