Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3610883..3611511 Replicon chromosome
Accession NZ_CP019948
Organism Methylocystis bryophila strain S285

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag B1812_RS17185 Protein ID WP_085772676.1
Coordinates 3611113..3611511 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag B1812_RS17180 Protein ID WP_085772675.1
Coordinates 3610883..3611116 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B1812_RS17165 3606699..3608960 - 2262 WP_085772673.1 TonB-dependent receptor -
B1812_RS17170 3609237..3610268 + 1032 WP_085773803.1 recombinase RecA -
B1812_RS17175 3610560..3610760 + 201 WP_102938216.1 exodeoxyribonuclease VII small subunit -
B1812_RS17180 3610883..3611116 + 234 WP_085772675.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
B1812_RS17185 3611113..3611511 + 399 WP_085772676.1 type II toxin-antitoxin system VapC family toxin Toxin
B1812_RS17190 3611585..3611920 - 336 WP_199768987.1 cupin domain-containing protein -
B1812_RS17195 3612039..3614009 - 1971 WP_085772677.1 protein meaA -
B1812_RS17200 3614460..3615206 - 747 WP_085772678.1 YebC/PmpR family DNA-binding transcriptional regulator -
B1812_RS17205 3615438..3616403 + 966 WP_085772679.1 TIGR00730 family Rossman fold protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

SpoVT-AbrB domain

(9-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14378.57 Da        Isoelectric Point: 5.2338

>T73562 WP_085772676.1 NZ_CP019948:3611113-3611511 [Methylocystis bryophila]
MKYLLDTNIISDLIKNPRGRAAEHIGRVGEVNVCTSMVVAAELRYGCVKAGSTRLAEAVEKLLAEIDLLPFEVPADAEYG
RLRARLEQQGKTIGSNDLLIAAHALAIDATIVTANVSEFSRVEGLRVENWLC

Download         Length: 399 bp

>T73562 NZ_CP019948:3611113-3611511 [Methylocystis bryophila]
CTGAAATATCTCTTAGACACCAACATCATCTCCGACCTGATAAAAAATCCTCGGGGCCGTGCCGCGGAGCACATCGGGCG
CGTCGGCGAGGTCAACGTCTGCACGAGCATGGTCGTGGCCGCCGAGCTTCGCTACGGATGCGTGAAAGCGGGCTCGACGC
GTCTTGCGGAAGCCGTCGAAAAGCTTCTAGCCGAGATTGACCTTCTTCCATTTGAAGTCCCGGCCGACGCGGAATATGGG
CGTCTTCGCGCGCGCCTTGAGCAGCAAGGGAAGACGATCGGCTCGAACGATCTCTTGATTGCCGCGCACGCTCTGGCCAT
AGACGCCACGATCGTCACGGCCAATGTCAGCGAGTTCTCGCGGGTGGAAGGATTGAGGGTCGAAAACTGGCTCTGTTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8939.38 Da        Isoelectric Point: 4.8660

>AT73562 WP_085772675.1 NZ_CP019948:3610883-3611116 [Methylocystis bryophila]
MEARRVRLFRNGRNQAVRIPVEFELPGDEALLLREGDRLVLLPTRKRGLLGLLATMEPLDEDFPEIEDRPPAPERMF

Download         Length: 234 bp

>AT73562 NZ_CP019948:3610883-3611116 [Methylocystis bryophila]
ATGGAAGCGAGGCGCGTGAGGCTGTTCAGAAACGGACGCAATCAAGCCGTGCGGATTCCTGTCGAATTCGAGTTGCCCGG
CGATGAGGCGCTCTTGCTGCGCGAAGGCGATCGTCTCGTGCTTTTGCCGACGCGTAAGCGCGGTCTCTTGGGCCTGCTCG
CGACGATGGAGCCTCTCGACGAGGACTTTCCCGAGATTGAGGATCGACCGCCAGCGCCGGAGCGAATGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References