Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2946601..2947229 Replicon chromosome
Accession NZ_CP019948
Organism Methylocystis bryophila strain S285

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag B1812_RS13940 Protein ID WP_085772130.1
Coordinates 2946601..2946996 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag B1812_RS13945 Protein ID WP_085772131.1
Coordinates 2946996..2947229 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B1812_RS13915 2942033..2942689 - 657 WP_085773723.1 DedA family protein -
B1812_RS13920 2942916..2944106 + 1191 WP_085772126.1 elongation factor Tu -
B1812_RS22685 2944343..2945230 + 888 WP_158658770.1 hypothetical protein -
B1812_RS13925 2945392..2945619 - 228 WP_085772127.1 hypothetical protein -
B1812_RS13930 2945716..2946225 - 510 WP_085772128.1 GNAT family N-acetyltransferase -
B1812_RS13935 2946229..2946531 - 303 WP_085772129.1 DUF1778 domain-containing protein -
B1812_RS13940 2946601..2946996 - 396 WP_085772130.1 PIN domain-containing protein Toxin
B1812_RS13945 2946996..2947229 - 234 WP_085772131.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
B1812_RS13950 2947391..2947615 - 225 WP_085772132.1 hypothetical protein -
B1812_RS13955 2947814..2948671 + 858 WP_085772133.1 DUF1499 domain-containing protein -
B1812_RS13960 2948637..2950445 - 1809 WP_085772134.1 M3 family oligoendopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

SpoVT-AbrB domain

(10-43)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14263.47 Da        Isoelectric Point: 6.4608

>T73561 WP_085772130.1 NZ_CP019948:c2946996-2946601 [Methylocystis bryophila]
MRYMLDTNICAAVIKRREKRVLGRFDAEAGRMCVSTITLSEILFGAEKKASPALDAAVRDLAACIGVVAYDEAAASHYGQ
LRAELERLGATLGANDLFIAAHARSLGLILVTDDAAFERVPGLRVENWLRE

Download         Length: 396 bp

>T73561 NZ_CP019948:c2946996-2946601 [Methylocystis bryophila]
ATGCGCTATATGCTCGACACGAATATTTGCGCCGCCGTCATCAAGCGGCGTGAAAAGAGGGTGTTAGGCAGGTTCGACGC
CGAGGCGGGACGCATGTGCGTCTCGACGATCACTTTGAGCGAAATATTGTTCGGCGCAGAAAAGAAAGCGAGCCCCGCCC
TCGACGCGGCGGTGCGCGACCTTGCCGCCTGCATCGGCGTGGTCGCTTACGACGAAGCCGCGGCCTCGCATTATGGGCAA
TTGCGCGCCGAGCTCGAACGACTGGGCGCGACGCTCGGCGCGAATGATCTCTTCATCGCCGCCCACGCCCGCTCATTGGG
GCTTATCCTCGTGACCGACGACGCGGCTTTTGAGCGCGTCCCGGGATTGCGGGTCGAGAATTGGCTGCGCGAGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8564.85 Da        Isoelectric Point: 7.0118

>AT73561 WP_085772131.1 NZ_CP019948:c2947229-2946996 [Methylocystis bryophila]
MTTAATTLFLSNKTQALRLPKAVAFPEGVKEVDIVVVGESRIVSPAGKRFTEWAKRHPPFPDFERPTQPPLDDEAIF

Download         Length: 234 bp

>AT73561 NZ_CP019948:c2947229-2946996 [Methylocystis bryophila]
ATGACCACCGCCGCCACCACCCTCTTTCTCAGCAATAAGACACAGGCCCTGCGCCTGCCGAAGGCCGTCGCTTTCCCTGA
GGGCGTCAAGGAGGTCGACATCGTCGTCGTCGGAGAATCGCGCATCGTCTCGCCCGCCGGCAAGAGATTCACCGAGTGGG
CCAAACGGCATCCGCCGTTCCCGGATTTCGAGCGCCCGACGCAGCCGCCGCTGGATGACGAAGCCATCTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References