Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbE-relB/ParE-YafN
Location 2395952..2396480 Replicon chromosome
Accession NZ_CP019948
Organism Methylocystis bryophila strain S285

Toxin (Protein)


Gene name stbE Uniprot ID -
Locus tag B1812_RS11175 Protein ID WP_085771662.1
Coordinates 2396190..2396480 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag B1812_RS11170 Protein ID WP_085771661.1
Coordinates 2395952..2396200 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B1812_RS11150 2391820..2392602 + 783 WP_085771657.1 ethanolamine ammonia-lyase subunit EutC -
B1812_RS11155 2392623..2392901 - 279 WP_085771658.1 hypothetical protein -
B1812_RS11160 2393212..2393916 + 705 WP_085771659.1 type 1 glutamine amidotransferase domain-containing protein -
B1812_RS11165 2393946..2395688 - 1743 WP_158658714.1 DUF885 domain-containing protein -
B1812_RS11170 2395952..2396200 + 249 WP_085771661.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
B1812_RS11175 2396190..2396480 + 291 WP_085771662.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B1812_RS11185 2396894..2398117 - 1224 WP_085771663.1 DNA modification methylase -
B1812_RS11190 2398240..2398569 - 330 WP_085773664.1 protease inhibitor I42 family protein -
B1812_RS11195 2398832..2400265 + 1434 WP_102938196.1 DUF1800 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11381.21 Da        Isoelectric Point: 10.5908

>T73560 WP_085771662.1 NZ_CP019948:2396190-2396480 [Methylocystis bryophila]
MTYELAFLDDALKEWRKLDSTTRDQFKIKLAERLENPKVISARLHGAKERYKIKLRSAGFRLVYEVRDQELIVLVVAVGK
RERNEVYKTAARRRTD

Download         Length: 291 bp

>T73560 NZ_CP019948:2396190-2396480 [Methylocystis bryophila]
ATGACCTATGAGCTCGCCTTTCTTGACGACGCGTTGAAGGAATGGCGCAAGCTGGATAGCACCACTCGAGACCAGTTCAA
GATCAAGCTCGCCGAGCGGCTGGAAAACCCGAAAGTTATCTCCGCTCGTTTGCATGGCGCGAAAGAGCGCTACAAGATCA
AGTTGCGTAGCGCTGGTTTCCGCCTAGTCTATGAAGTTCGCGATCAGGAGTTGATCGTTCTTGTCGTGGCGGTCGGCAAG
CGCGAGCGCAACGAAGTTTACAAGACCGCCGCACGGCGGCGGACGGATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8874.12 Da        Isoelectric Point: 4.5494

>AT73560 WP_085771661.1 NZ_CP019948:2395952-2396200 [Methylocystis bryophila]
MAHIVHATTVASISDLKKNPMGTVAAGEGFPVAILNRNEPAFYCIPAKAYEDLLERLEDLELNAVADAREGQAIHKISLD
DL

Download         Length: 249 bp

>AT73560 NZ_CP019948:2395952-2396200 [Methylocystis bryophila]
ATGGCGCATATCGTTCACGCGACCACGGTCGCGAGCATTTCGGATTTGAAGAAGAACCCCATGGGCACCGTTGCCGCCGG
CGAAGGGTTCCCCGTTGCGATCCTCAACCGCAACGAGCCTGCGTTCTATTGCATCCCTGCCAAGGCTTATGAAGATTTGC
TGGAGCGTCTCGAAGACCTCGAGCTGAACGCCGTTGCGGACGCGCGCGAAGGGCAGGCGATCCACAAGATTTCGCTCGAT
GACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References