Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 982778..983481 Replicon chromosome
Accession NZ_CP019948
Organism Methylocystis bryophila strain S285

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag B1812_RS04465 Protein ID WP_085770515.1
Coordinates 983074..983481 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag B1812_RS04460 Protein ID WP_085770514.1
Coordinates 982778..983065 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B1812_RS04430 978094..978285 + 192 WP_158658595.1 LLM class flavin-dependent oxidoreductase -
B1812_RS04435 978371..979612 + 1242 WP_085770510.1 SfnB family sulfur acquisition oxidoreductase -
B1812_RS04440 979780..980427 + 648 Protein_862 LysR family transcriptional regulator -
B1812_RS04445 980721..981650 + 930 WP_085770511.1 MBL fold metallo-hydrolase -
B1812_RS04455 982145..982498 - 354 WP_085770513.1 DsrE family protein -
B1812_RS04460 982778..983065 + 288 WP_085770514.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
B1812_RS04465 983074..983481 + 408 WP_085770515.1 PIN domain-containing protein Toxin
B1812_RS04470 983591..985198 - 1608 WP_085770516.1 efflux transporter outer membrane subunit -
B1812_RS04475 985195..986394 - 1200 WP_085770517.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-126)

Antitoxin

SpoVT-AbrB domain

(18-54)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14918.15 Da        Isoelectric Point: 6.3580

>T73559 WP_085770515.1 NZ_CP019948:983074-983481 [Methylocystis bryophila]
MFCLDTNIVIFALNKRRPWIATRLDNELRAGTALIVPAIVLFELNYGIAKSDRADQARALLDGFLSAGIGQPAFDAEDAR
EAADIRAFLERQGTPIGPFDYLVAAQARRRGAALVTLNRREFERVPGLMVTDWAA

Download         Length: 408 bp

>T73559 NZ_CP019948:983074-983481 [Methylocystis bryophila]
ATGTTTTGTCTCGACACGAACATCGTCATCTTCGCCTTGAACAAGCGGAGGCCCTGGATCGCCACGAGGCTCGATAATGA
GCTGAGGGCGGGAACGGCGCTCATCGTCCCCGCGATCGTGCTGTTCGAGCTCAACTACGGAATCGCCAAGAGCGACCGAG
CCGATCAAGCGCGCGCCCTGCTCGATGGCTTCTTGTCCGCCGGGATAGGCCAGCCGGCCTTCGACGCGGAGGATGCGCGC
GAGGCCGCGGACATAAGGGCGTTCCTCGAACGGCAAGGGACGCCGATCGGCCCCTTCGACTATCTCGTCGCGGCGCAGGC
GCGGCGGCGCGGCGCGGCGCTGGTGACGCTCAACCGCCGCGAGTTCGAGCGCGTGCCCGGCCTGATGGTGACGGATTGGG
CGGCATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10494.93 Da        Isoelectric Point: 4.9057

>AT73559 WP_085770514.1 NZ_CP019948:982778-983065 [Methylocystis bryophila]
MTASAGKPAQEKATAKLFMHGRSQAVRLPKEFRFEGKEVRVSKVGDKVILEPLKKEPFDVEAWRGSLDALGARDFLPDGL
PDDPPLEPDDSISFD

Download         Length: 288 bp

>AT73559 NZ_CP019948:982778-983065 [Methylocystis bryophila]
ATGACCGCCAGCGCCGGCAAGCCCGCCCAAGAGAAAGCGACCGCCAAGCTGTTCATGCACGGCCGCAGCCAGGCTGTGCG
CCTGCCGAAGGAGTTCCGCTTCGAGGGGAAAGAGGTGCGCGTCAGCAAGGTAGGCGACAAGGTGATCTTGGAGCCTTTGA
AAAAGGAGCCGTTCGACGTGGAAGCCTGGCGCGGGAGTCTCGACGCCTTGGGCGCGCGGGATTTCTTGCCCGACGGTCTG
CCCGATGATCCGCCCCTCGAGCCCGACGATTCGATATCATTCGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References