Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 745388..745997 Replicon chromosome
Accession NZ_CP019948
Organism Methylocystis bryophila strain S285

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag B1812_RS03390 Protein ID WP_085770347.1
Coordinates 745812..745997 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag B1812_RS03385 Protein ID WP_085770346.1
Coordinates 745388..745807 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B1812_RS03370 741860..742525 + 666 WP_085773468.1 M15 family metallopeptidase -
B1812_RS03375 742577..743632 + 1056 WP_085770344.1 NAD(P)-dependent alcohol dehydrogenase -
B1812_RS03380 743744..745348 - 1605 WP_085770345.1 peptide chain release factor 3 -
B1812_RS03385 745388..745807 - 420 WP_085770346.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
B1812_RS03390 745812..745997 - 186 WP_085770347.1 type II toxin-antitoxin system HicA family toxin Toxin
B1812_RS03395 746065..746673 - 609 WP_085770348.1 cob(I)yrinic acid a,c-diamide adenosyltransferase -
B1812_RS03400 746670..747131 - 462 WP_085770349.1 preQ(1) synthase -
B1812_RS03405 747189..748052 - 864 WP_085770350.1 DUF2778 domain-containing protein -
B1812_RS03415 748672..749094 + 423 WP_085770352.1 hypothetical protein -
B1812_RS03420 749246..750886 - 1641 WP_085770353.1 2-isopropylmalate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-62)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6485.69 Da        Isoelectric Point: 11.1039

>T73558 WP_085770347.1 NZ_CP019948:c745997-745812 [Methylocystis bryophila]
MNSAQAKRYLAKKGATFAPGKGGPLIVTLNGKRSVLPQHGGSKEIGKGLWLAILKQLDIKE

Download         Length: 186 bp

>T73558 NZ_CP019948:c745997-745812 [Methylocystis bryophila]
ATGAACAGCGCTCAGGCCAAGCGCTATCTGGCCAAGAAGGGCGCAACCTTCGCGCCTGGCAAAGGCGGCCCTCTGATCGT
GACGCTGAATGGCAAGCGCTCGGTGCTCCCGCAGCACGGCGGGTCGAAGGAGATCGGCAAGGGCCTGTGGCTGGCAATCT
TGAAGCAACTCGACATCAAGGAGTGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 14863.17 Da        Isoelectric Point: 5.2520

>AT73558 WP_085770346.1 NZ_CP019948:c745807-745388 [Methylocystis bryophila]
MRYAVTLVPDDNGTLLVTAPDIPEAVTFGEDREDALARAADAIETAIMGFMSAREDIPSPKAKGQDYVSLAALSVAKIEL
YRAMRADGVGKAALAKRLGVALPQIDRLLDLRHASRLDAIERAFAALGRTMEVVIRAAA

Download         Length: 420 bp

>AT73558 NZ_CP019948:c745807-745388 [Methylocystis bryophila]
ATGCGCTACGCCGTGACTCTCGTTCCCGACGACAATGGTACGCTTCTCGTCACCGCGCCTGATATTCCCGAGGCCGTCAC
CTTTGGCGAGGACCGGGAAGACGCGCTGGCGCGCGCCGCCGACGCCATCGAAACCGCGATCATGGGCTTCATGTCGGCGC
GCGAGGACATCCCGTCCCCCAAGGCGAAAGGGCAGGACTACGTCTCCTTGGCCGCGCTCTCCGTCGCCAAGATCGAGCTT
TACCGCGCCATGCGGGCGGATGGAGTCGGCAAGGCGGCGCTCGCCAAGCGCCTCGGCGTCGCTTTGCCGCAGATTGACCG
GCTGCTCGACCTTCGCCACGCTTCCCGCCTCGATGCGATCGAGCGGGCCTTTGCCGCGCTGGGGCGAACCATGGAGGTTG
TCATCAGAGCCGCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References