Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 32718..33379 Replicon chromosome
Accession NZ_CP019947
Organism Pseudomonas sp. CC6-YY-74

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag B2D37_RS00160 Protein ID WP_079200832.1
Coordinates 32960..33379 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag B2D37_RS00155 Protein ID WP_079200831.1
Coordinates 32718..32963 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B2D37_RS00130 28531..29064 - 534 WP_079200827.1 DUF3087 domain-containing protein -
B2D37_RS00135 29318..29896 - 579 WP_079200828.1 S-(hydroxymethyl)glutathione synthase -
B2D37_RS22920 30017..30244 - 228 WP_154067008.1 hypothetical protein -
B2D37_RS00140 30593..30868 + 276 WP_079200829.1 hypothetical protein -
B2D37_RS00145 31037..31696 + 660 Protein_19 hypothetical protein -
B2D37_RS00150 31693..32682 + 990 WP_079200830.1 tyrosine-type recombinase/integrase -
B2D37_RS00155 32718..32963 + 246 WP_079200831.1 plasmid stabilization protein Antitoxin
B2D37_RS00160 32960..33379 + 420 WP_079200832.1 type II toxin-antitoxin system VapC family toxin Toxin
B2D37_RS00165 33466..33792 + 327 WP_079200833.1 excalibur calcium-binding domain-containing protein -
B2D37_RS00175 34048..35145 - 1098 WP_079200834.1 redox-regulated ATPase YchF -
B2D37_RS00180 35166..35756 - 591 WP_079200835.1 aminoacyl-tRNA hydrolase -
B2D37_RS00185 35826..36461 - 636 WP_079200836.1 50S ribosomal protein L25/general stress protein Ctc -
B2D37_RS00190 36577..37518 - 942 WP_079204847.1 ribose-phosphate pyrophosphokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15111.32 Da        Isoelectric Point: 4.4185

>T73556 WP_079200832.1 NZ_CP019947:32960-33379 [Pseudomonas sp. CC6-YY-74]
MILLDTNVLSELMRAKPAAEVLAWVDAQPSSELFTSAITVAEILYGIARMPDGKRKDGLLELATLMFEEDFSGRILPFDT
EAAVHYAGLAAESEAKGRVVDMADGQIAAIAALHDARVATRNVRHFDYLGVPVINPWEA

Download         Length: 420 bp

>T73556 NZ_CP019947:32960-33379 [Pseudomonas sp. CC6-YY-74]
ATGATCTTGCTGGATACCAACGTGCTTTCAGAGTTGATGCGGGCCAAGCCTGCTGCTGAAGTCTTGGCGTGGGTTGATGC
CCAGCCTTCAAGCGAGCTGTTCACCAGTGCCATCACCGTTGCTGAAATTCTCTACGGCATCGCCCGCATGCCTGACGGCA
AGCGTAAGGACGGTTTGTTAGAGCTGGCGACGCTGATGTTCGAAGAGGATTTTTCTGGCCGTATTCTTCCGTTTGATACA
GAAGCGGCTGTTCACTATGCCGGCTTAGCCGCTGAGAGTGAGGCGAAAGGGAGGGTCGTGGATATGGCCGATGGGCAGAT
CGCTGCCATTGCCGCTTTGCATGATGCGCGAGTCGCTACGCGCAATGTTCGGCACTTTGACTACCTGGGCGTTCCCGTTA
TCAATCCTTGGGAGGCTTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8806.04 Da        Isoelectric Point: 10.1758

>AT73556 WP_079200831.1 NZ_CP019947:32718-32963 [Pseudomonas sp. CC6-YY-74]
MASITIRNLDDDIKAQLRVVAASHGRSMEEEVRVIIRHALFKSEKSGGLGSRINARFAAVGGVDLEVPARKDKARAASFD
E

Download         Length: 246 bp

>AT73556 NZ_CP019947:32718-32963 [Pseudomonas sp. CC6-YY-74]
ATGGCCAGCATCACTATTCGAAACCTAGACGACGACATCAAGGCTCAACTGCGTGTTGTTGCCGCAAGCCATGGCCGTTC
GATGGAAGAAGAGGTCAGGGTCATTATTCGCCATGCGCTGTTTAAGTCAGAAAAAAGCGGTGGCTTGGGTAGTCGCATCA
ATGCTCGATTCGCTGCCGTTGGTGGGGTGGATCTCGAAGTGCCTGCTCGCAAGGACAAGGCCCGTGCCGCGAGCTTTGAC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References