Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2230256..2230770 Replicon chromosome
Accession NZ_CP019945
Organism Staphylococcus aureus strain BA01611

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag AOZ05_RS11735 Protein ID WP_000581793.1
Coordinates 2230256..2230465 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag AOZ05_RS11740 Protein ID WP_000138932.1
Coordinates 2230477..2230770 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOZ05_RS11715 2225765..2227123 - 1359 WP_000611482.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
AOZ05_RS11720 2227138..2228208 - 1071 WP_054249671.1 D-alanine--D-alanine ligase -
AOZ05_RS11725 2228526..2229728 + 1203 WP_031590208.1 rod shape-determining protein RodA -
AOZ05_RS11730 2229991..2230128 - 138 WP_000828354.1 hypothetical protein -
AOZ05_RS11735 2230256..2230465 - 210 WP_000581793.1 heavy-metal-associated domain-containing protein Toxin
AOZ05_RS11740 2230477..2230770 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
AOZ05_RS11745 2230936..2232420 + 1485 WP_000571549.1 cardiolipin synthase -
AOZ05_RS11750 2232448..2233095 + 648 WP_031590210.1 HD domain-containing protein -
AOZ05_RS11765 2233709..2234581 - 873 WP_000725802.1 membrane protein insertase YidC -
AOZ05_RS11770 2234667..2235308 - 642 WP_000483155.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T73549 WP_000581793.1 NZ_CP019945:c2230465-2230256 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T73549 NZ_CP019945:c2230465-2230256 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT73549 WP_000138932.1 NZ_CP019945:c2230770-2230477 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT73549 NZ_CP019945:c2230770-2230477 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References