Detailed information of TA system TA073547

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_19(antitoxin)
• Location: 2070242..2071030
• Replicon: chromosome
• Accession: NZ_CP019945
• Organism: Staphylococcus aureus strain BA01611

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: AOZ05_RS10885
• Protein ID: WP_054249689.1
• Coordinates: 2070569..2071030 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E7YIA0
• Locus tag: AOZ05_RS10880
• Protein ID: WP_000333630.1
• Coordinates: 2070242..2070556 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AOZ05_RS10815	2065496..2065954	-	459	WP_054249651.1	single-stranded DNA-binding protein	-
AOZ05_RS10820	2065954..2066577	-	624	WP_000139720.1	DUF1071 domain-containing protein	-
AOZ05_RS10825	2066570..2066791	-	222	WP_000815402.1	DUF2483 family protein	-
AOZ05_RS10830	2066801..2067061	-	261	WP_031902393.1	DUF1108 family protein	-
AOZ05_RS10835	2067103..2067369	-	267	WP_031902392.1	DUF2482 family protein	-
AOZ05_RS10840	2067462..2067623	-	162	WP_054249693.1	DUF1270 family protein	-
AOZ05_RS10845	2067616..2067837	-	222	WP_000594789.1	hypothetical protein	-
AOZ05_RS10850	2067908..2068117	+	210	WP_000642492.1	hypothetical protein	-
AOZ05_RS10855	2068107..2068250	-	144	WP_054249692.1	hypothetical protein	-
AOZ05_RS10860	2068266..2069018	-	753	WP_054249691.1	phage antirepressor KilAC domain-containing protein	-
AOZ05_RS10865	2069078..2069560	+	483	WP_000394410.1	hypothetical protein	-
AOZ05_RS10870	2069661..2069840	-	180	WP_000438352.1	hypothetical protein	-
AOZ05_RS10875	2069854..2070090	-	237	WP_054249690.1	helix-turn-helix transcriptional regulator	-
AOZ05_RS10880	2070242..2070556	+	315	WP_000333630.1	helix-turn-helix domain-containing protein	Antitoxin
AOZ05_RS10885	2070569..2071030	+	462	WP_054249689.1	toxin	Toxin
AOZ05_RS10890	2071047..2071550	+	504	WP_054249688.1	hypothetical protein	-
AOZ05_RS10895	2071613..2072659	+	1047	WP_031865288.1	site-specific integrase	-
AOZ05_RS10900	2072704..2073849	+	1146	WP_054249687.1	radical SAM/CxCxxxxC motif protein YfkAB	-
AOZ05_RS10905	2074109..2074639	-	531	WP_000184383.1	acyl-CoA thioesterase	-
AOZ05_RS10910	2074729..2075985	-	1257	WP_001789555.1	aminopeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2025831..2072659	46828

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (4-62)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18136.46 Da
• Isoelectric Point: 4.5232

>T73547 WP_054249689.1 NZ_CP019945:2070569-2071030 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHDFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKMYGIGTHYGEYSITFEPLRVFKYKEI

Nucleotide

• Length: 462 bp

>T73547 NZ_CP019945:2070569-2071030 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTGATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCGCATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCACGT
AGACACGACTTTATCTCAGCTGTTCCATTACGTGAAATTGTAGAAGCTTATAATTATGGCGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTGGAGGCGATAGAACAATATAAGAAGATGTATGGTATTGGTACTC
ACTACGGTGAATACTCAATTACATTTGAACCGTTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12063.56 Da
• Isoelectric Point: 6.4736

>AT73547 WP_000333630.1 NZ_CP019945:2070242-2070556 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 315 bp

>AT73547 NZ_CP019945:2070242-2070556 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGCGGAAATATCAAAAATCTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCGTATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCATTTA
GAAGGAGAATTAACTGATGACGAGTGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0E7YIA0