Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 944231..944708 Replicon chromosome
Accession NZ_CP019945
Organism Staphylococcus aureus strain BA01611

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag AOZ05_RS04995 Protein ID WP_000052076.1
Coordinates 944231..944419 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag AOZ05_RS05000 Protein ID WP_001059690.1
Coordinates 944448..944708 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOZ05_RS04965 940266..940742 + 477 WP_000824477.1 hypothetical protein -
AOZ05_RS04970 941083..941769 + 687 WP_001641381.1 thermonuclease family protein -
AOZ05_RS04975 942126..942326 + 201 WP_001059082.1 cold-shock protein -
AOZ05_RS04980 942822..943040 - 219 WP_000005887.1 hypothetical protein -
AOZ05_RS04985 943102..943386 - 285 WP_031590186.1 hypothetical protein -
AOZ05_RS04990 943474..944043 - 570 WP_001106652.1 hypothetical protein -
AOZ05_RS04995 944231..944419 - 189 WP_000052076.1 hypothetical protein Toxin
AOZ05_RS05000 944448..944708 - 261 WP_001059690.1 hypothetical protein Antitoxin
AOZ05_RS05005 945049..945252 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
AOZ05_RS05010 945249..945485 - 237 WP_000368687.1 hypothetical protein -
AOZ05_RS05015 945710..946291 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
AOZ05_RS05020 946364..946981 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
AOZ05_RS05025 947137..947631 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
AOZ05_RS05030 948030..948452 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
AOZ05_RS05035 948600..949316 + 717 WP_031589686.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 881511..949938 68427


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T73542 WP_000052076.1 NZ_CP019945:c944419-944231 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T73542 NZ_CP019945:c944419-944231 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT73542 WP_001059690.1 NZ_CP019945:c944708-944448 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT73542 NZ_CP019945:c944708-944448 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References