Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4830597..4831432 Replicon chromosome
Accession NZ_CP019944
Organism Escherichia coli strain DSM 103246

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7W3AJH4
Locus tag Eco28_RS24705 Protein ID WP_000854721.1
Coordinates 4831055..4831432 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1L4J164
Locus tag Eco28_RS24700 Protein ID WP_001406130.1
Coordinates 4830597..4830965 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Eco28_RS24675 4828263..4829081 + 819 WP_072647787.1 DUF945 domain-containing protein -
Eco28_RS24680 4829173..4829658 + 486 WP_072647786.1 antirestriction protein -
Eco28_RS24685 4829674..4830150 + 477 WP_001186747.1 RadC family protein -
Eco28_RS24690 4830213..4830434 + 222 WP_001405861.1 DUF987 domain-containing protein -
Eco28_RS24700 4830597..4830965 + 369 WP_001406130.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
Eco28_RS24705 4831055..4831432 + 378 WP_000854721.1 TA system toxin CbtA family protein Toxin
Eco28_RS24710 4831429..4831917 + 489 WP_072647689.1 hypothetical protein -
Eco28_RS24715 4831929..4832126 + 198 WP_000839239.1 DUF957 domain-containing protein -
Eco28_RS24720 4832211..4833077 + 867 WP_072647690.1 DUF4942 domain-containing protein -
Eco28_RS24725 4833149..4833412 + 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
Eco28_RS24730 4833409..4833735 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
Eco28_RS24735 4834199..4835461 + 1263 WP_001218820.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island aph(3'')-Ib / aph(6)-Id / aph(3')-Ia / tet(B) / sul2 papG / papF / papE / papK / papJ / papD / papC / papH / papA / papB / papI 4801852..4875094 73242


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14089.12 Da        Isoelectric Point: 8.2904

>T73539 WP_000854721.1 NZ_CP019944:4831055-4831432 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T73539 NZ_CP019944:4831055-4831432 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGGTTC
AGCACCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13717.53 Da        Isoelectric Point: 7.0269

>AT73539 WP_001406130.1 NZ_CP019944:4830597-4830965 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYLAVYPTSETKK

Download         Length: 369 bp

>AT73539 NZ_CP019944:4830597-4830965 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCAGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W3AJH4

Antitoxin

Source ID Structure
AlphaFold DB A0A1L4J164

References