Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2475928..2476454 Replicon chromosome
Accession NZ_CP019944
Organism Escherichia coli strain DSM 103246

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag Eco28_RS12840 Protein ID WP_000323025.1
Coordinates 2476167..2476454 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag Eco28_RS12835 Protein ID WP_000534858.1
Coordinates 2475928..2476167 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Eco28_RS12800 2471114..2471341 + 228 WP_000476993.1 transcriptional regulator -
Eco28_RS12805 2471325..2471846 + 522 WP_000705349.1 hypothetical protein -
Eco28_RS12810 2471827..2472792 + 966 WP_000054504.1 hypothetical protein -
Eco28_RS12815 2472833..2473252 + 420 WP_001151195.1 DUF977 family protein -
Eco28_RS12820 2473286..2474626 + 1341 WP_004196353.1 ISNCY family transposase -
Eco28_RS12825 2475063..2475395 - 333 WP_001301033.1 protein FlxA -
Eco28_RS12830 2475598..2475903 - 306 WP_001326990.1 hypothetical protein -
Eco28_RS12835 2475928..2476167 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
Eco28_RS12840 2476167..2476454 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
Eco28_RS12845 2476526..2476681 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
Eco28_RS12850 2476898..2477149 + 252 WP_000980994.1 hypothetical protein -
Eco28_RS12855 2477216..2477494 + 279 WP_012304870.1 hypothetical protein -
Eco28_RS12860 2477496..2478545 + 1050 WP_001265198.1 DUF968 domain-containing protein -
Eco28_RS12865 2478559..2479311 + 753 WP_001047135.1 antitermination protein -
Eco28_RS28100 2479589..2479678 - 90 WP_120795389.1 hypothetical protein -
Eco28_RS12870 2479733..2479945 - 213 WP_000087756.1 cold shock-like protein CspF -
Eco28_RS12875 2480246..2480461 + 216 WP_000066484.1 cold shock-like protein CspB -
Eco28_RS28620 2480825..2480995 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
Eco28_RS12880 2481215..2481430 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2452882..2529935 77053


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T73528 WP_000323025.1 NZ_CP019944:2476167-2476454 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T73528 NZ_CP019944:2476167-2476454 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT73528 WP_000534858.1 NZ_CP019944:2475928-2476167 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT73528 NZ_CP019944:2475928-2476167 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References