Detailed information of TA system TA073509

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1070696..1071323
• Replicon: chromosome
• Accession: NZ_CP019937
• Organism: Ketogulonicigenium robustum strain SPU_B003

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: BVG79_RS05500
• Protein ID: WP_085787265.1
• Coordinates: 1071135..1071323 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: BVG79_RS05495
• Protein ID: WP_085786005.1
• Coordinates: 1070696..1071094 (-)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BVG79_RS05475	1066596..1066910	+	315	WP_085786001.1	hypothetical protein	-
BVG79_RS05480	1066910..1069594	+	2685	WP_085786002.1	hypothetical protein	-
BVG79_RS05485	1069607..1070338	+	732	WP_085786003.1	hypothetical protein	-
BVG79_RS05490	1070399..1070695	+	297	WP_085786004.1	hypothetical protein	-
BVG79_RS05495	1070696..1071094	-	399	WP_085786005.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BVG79_RS05500	1071135..1071323	-	189	WP_085787265.1	type II toxin-antitoxin system HicA family toxin	Toxin
BVG79_RS05505	1071468..1072046	+	579	WP_085786006.1	hypothetical protein	-
BVG79_RS05510	1072043..1072246	+	204	WP_085786007.1	hypothetical protein	-
BVG79_RS13485	1072355..1072573	+	219	WP_157115633.1	hypothetical protein	-
BVG79_RS05520	1072723..1073247	-	525	WP_085786009.1	tyrosine-type recombinase/integrase	-
BVG79_RS05525	1073323..1073934	-	612	Protein_1061	IS3 family transposase	-
BVG79_RS05530	1074301..1074599	+	299	Protein_1062	hypothetical protein	-
BVG79_RS05535	1074620..1075603	-	984	WP_085786010.1	Hint domain-containing protein	-
BVG79_RS13635	1075849..1076121	+	273	WP_085786011.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1034202..1079547	45345
	-	flank	IS/Tn	-	-	1073323..1073670	347

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (8-61)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 6952.22 Da
• Isoelectric Point: 10.5481

>T73509 WP_085787265.1 NZ_CP019937:c1071323-1071135 [Ketogulonicigenium robustum]
MELETNSRKLLKVLKDAGFEEVSKRGSHLKLRKGDQVVILPHPKKDLPLGTVKSIYQQAGLL

Nucleotide

• Length: 189 bp

>T73509 NZ_CP019937:c1071323-1071135 [Ketogulonicigenium robustum]
ATGGAGTTAGAGACCAACTCACGAAAGCTTCTGAAGGTTTTGAAAGATGCAGGGTTCGAGGAAGTATCCAAACGCGGATC
ACACCTCAAACTACGTAAAGGGGATCAGGTCGTGATCCTGCCCCACCCCAAGAAAGACCTGCCGCTCGGAACCGTCAAAA
GCATCTACCAACAGGCGGGGCTGCTCTAG

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14160.07 Da
• Isoelectric Point: 4.4752

>AT73509 WP_085786005.1 NZ_CP019937:c1071094-1070696 [Ketogulonicigenium robustum]
MRYYTAIIHKDEGSAYGLTFPDLPGAFAAADTWDDIPKAATEALDLWFEDQPDVAPAPLDAVRARPDVAAELAAGAVLMP
VPYIAADTALERVNISIERGLLRAIDETAKSRKMTRSSFLASAARRELVGAG

Nucleotide

• Length: 399 bp

>AT73509 NZ_CP019937:c1071094-1070696 [Ketogulonicigenium robustum]
ATGCGTTATTACACCGCCATCATCCACAAAGACGAAGGCAGCGCCTACGGCCTGACCTTCCCTGATTTGCCCGGTGCCTT
CGCTGCCGCCGATACATGGGACGATATCCCCAAGGCTGCAACAGAAGCCCTCGATCTCTGGTTCGAGGATCAGCCGGACG
TTGCCCCTGCTCCGCTGGACGCTGTTCGCGCACGCCCCGATGTCGCCGCAGAATTAGCCGCTGGCGCGGTGCTGATGCCC
GTGCCCTACATCGCCGCAGATACCGCGCTCGAGCGCGTGAACATCAGCATCGAGCGCGGATTGCTACGCGCGATCGATGA
GACCGCTAAGTCGCGTAAGATGACCCGCTCATCATTCCTTGCCAGCGCCGCCCGCCGCGAGCTGGTTGGCGCTGGCTGA