Detailed information of TA system TA073507

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2878801..2879462
• Replicon: chromosome
• Accession: NZ_CP019934
• Organism: Bordetella bronchiseptica strain E016

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C6NZK6
• Locus tag: B2C13_RS13555
• Protein ID: WP_003817075.1
• Coordinates: 2879037..2879462 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: B2C13_RS13550
• Protein ID: WP_003812071.1
• Coordinates: 2878801..2879040 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B2C13_RS13515	2873830..2874633	-	804	WP_033447221.1	bacteriocin family protein	-
B2C13_RS13520	2874630..2875676	-	1047	WP_003812057.1	Dyp-type peroxidase	-
B2C13_RS13525	2875754..2876314	-	561	WP_003812059.1	DUF488 domain-containing protein	-
B2C13_RS13530	2876311..2876544	-	234	WP_033447224.1	DUF2945 domain-containing protein	-
B2C13_RS13535	2876625..2877137	-	513	WP_015041573.1	redoxin domain-containing protein	-
B2C13_RS13540	2877196..2877741	-	546	WP_033447227.1	peroxidase-related enzyme	-
B2C13_RS13545	2877885..2878727	+	843	WP_033448622.1	AraC family transcriptional regulator	-
B2C13_RS13550	2878801..2879040	+	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
B2C13_RS13555	2879037..2879462	+	426	WP_003817075.1	PIN domain-containing protein	Toxin
B2C13_RS13560	2879572..2880036	+	465	WP_003812075.1	MarR family transcriptional regulator	-
B2C13_RS13565	2880134..2881639	-	1506	WP_003812078.1	tripartite tricarboxylate transporter permease	-
B2C13_RS13570	2882138..2882650	+	513	WP_003812080.1	hypothetical protein	-
B2C13_RS13575	2882671..2883648	-	978	WP_033448428.1	tripartite tricarboxylate transporter substrate binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14813.19 Da
• Isoelectric Point: 6.3704

>T73507 WP_003817075.1 NZ_CP019934:2879037-2879462 [Bordetella bronchiseptica]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRILPLFMGHVLPFDA
AAADAYAAVMMRAAAAGHALCATDGCIAAIATAHGLAIATRHPARFEAAGLTAVDPWHAAA

Nucleotide

• Length: 426 bp

>T73507 NZ_CP019934:2879037-2879462 [Bordetella bronchiseptica]
ATGATCCTGCTCGACACCGACGTGCTGCTCGAACCGCTGCGGCCGGCCCCCGACCCGGCCGTCGCGGCATGGCTGGATGC
CCAGCACGTCGAAACCCTGTACCTGGCCGCGCCCGGCGCGGCCGAAATCCAGCTCGGCCTGGCCCGTCTGCCGCGCGGCA
AGCGGGCCGAGGCCCTGCGCCACGAATTCGAGCGGCGCATCCTGCCGCTGTTCATGGGCCATGTCCTGCCTTTCGACGCG
GCCGCGGCCGATGCCTACGCCGCCGTCATGATGCGGGCCGCGGCGGCGGGCCATGCGCTGTGCGCGACCGATGGCTGCAT
CGCCGCCATCGCCACCGCGCACGGGCTGGCCATCGCCACGCGCCATCCGGCCAGGTTCGAGGCGGCCGGGCTCACCGCCG
TCGATCCCTGGCACGCCGCCGCTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT73507 WP_003812071.1 NZ_CP019934:2878801-2879040 [Bordetella bronchiseptica]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT73507 NZ_CP019934:2878801-2879040 [Bordetella bronchiseptica]
GTGTCTTCGATTACGGTAAGAAATGTTCCCGAGGAAGTGCATCGCGCCTTGCGCGTACGCGCGGCCACACATGGGCGCAG
CACCGAGGCCGAGATCCGCGCCATCCTGGAAAACGCCGTGCTGCCCGATGGCCGCGTCAAGCTGGGCACCCTGCTCAGCC
ACATCGGCCGCGGCGCGCGCGGCATGGACCTGACCATCGAGCGCAATCCGGCGCCCGCCCGCCCGGCCAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: A0A0C6NZK6