Detailed information of TA system TA073491

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapB(antitoxin)
• Location: 3731059..3731621
• Replicon: chromosome
• Accession: NZ_CP019913
• Organism: Desulfococcus multivorans strain DSM 2059

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: S7UUL9
• Locus tag: B2D07_RS16365
• Protein ID: WP_020877879.1
• Coordinates: 3731256..3731621 (+)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: B2D07_RS16360
• Protein ID: WP_040416134.1
• Coordinates: 3731059..3731253 (+)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B2D07_RS16340	3726866..3727168	+	303	WP_020877875.1	hypothetical protein	-
B2D07_RS16345	3727227..3727727	-	501	WP_020877876.1	DUF255 domain-containing protein	-
B2D07_RS16350	3727921..3729765	-	1845	WP_144016391.1	thioredoxin family protein	-
B2D07_RS16355	3729805..3730656	-	852	WP_020877878.1	pyrroline-5-carboxylate reductase	-
B2D07_RS16360	3731059..3731253	+	195	WP_040416134.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
B2D07_RS16365	3731256..3731621	+	366	WP_020877879.1	PIN domain-containing protein	Toxin
B2D07_RS16370	3731726..3732559	+	834	WP_020877880.1	hypothetical protein	-
B2D07_RS16375	3732559..3732852	+	294	WP_040416137.1	hypothetical protein	-
B2D07_RS16380	3732882..3733181	+	300	WP_020877882.1	YggT family protein	-
B2D07_RS16385	3733238..3734320	+	1083	WP_020877883.1	type IV pilus twitching motility protein PilT	-
B2D07_RS16390	3734344..3735498	+	1155	WP_020877884.1	PilT/PilU family type 4a pilus ATPase	-
B2D07_RS16395	3735495..3736172	+	678	WP_020877885.1	transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-111)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (2-42)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 13361.66 Da
• Isoelectric Point: 5.0870

>T73491 WP_020877879.1 NZ_CP019913:3731256-3731621 [Desulfococcus multivorans]
MILADTNVWIKHFRESDAELIEHLNMGFVACHPFIIGELACGNIGNRAEILTLLKALPAAPIVEPRELLNFIENNMLMGR
GLGYVDIQILASAIIGNVVLWTFDRRLNAAATELGVSYLKS

Nucleotide

• Length: 366 bp

>T73491 NZ_CP019913:3731256-3731621 [Desulfococcus multivorans]
ATGATTCTTGCCGATACCAACGTTTGGATCAAACATTTCAGAGAGTCCGATGCTGAACTCATTGAGCATTTGAACATGGG
TTTTGTGGCATGCCACCCGTTTATTATCGGTGAATTGGCCTGCGGCAATATAGGGAATCGGGCGGAAATTCTGACGCTCC
TCAAGGCGCTGCCCGCCGCACCCATTGTTGAACCGAGAGAACTTTTGAATTTTATAGAAAATAACATGCTGATGGGGCGC
GGTCTCGGCTACGTGGATATTCAGATACTGGCTTCCGCGATTATCGGTAACGTCGTACTATGGACTTTTGATCGTCGTCT
GAATGCGGCGGCAACGGAGTTGGGCGTTTCATATTTGAAAAGCTGA

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7244.35 Da
• Isoelectric Point: 10.7279

>AT73491 WP_040416134.1 NZ_CP019913:3731059-3731253 [Desulfococcus multivorans]
VRTTLNIEDDLIERASDLTGIKEKTALVRKGLEALISLESSRRLAALGGTEKDLRMPRRRRPEQ

Nucleotide

• Length: 195 bp

>AT73491 NZ_CP019913:3731059-3731253 [Desulfococcus multivorans]
GTGAGAACAACATTGAACATCGAGGACGACCTCATCGAAAGAGCGTCGGACCTTACCGGAATAAAAGAAAAAACAGCTCT
TGTCCGCAAAGGACTCGAAGCCCTGATCAGTTTGGAGAGCAGCAGGCGCCTGGCTGCACTGGGTGGAACCGAGAAAGATC
TCCGGATGCCAAGGCGAAGACGACCGGAGCAATAA

Structures

Toxin

• AlphaFold DB: S7UUL9