Detailed information of TA system TA073489

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1830224..1830838
• Replicon: chromosome
• Accession: NZ_CP019913
• Organism: Desulfococcus multivorans strain DSM 2059

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: B2D07_RS07985
• Protein ID: WP_078081235.1
• Coordinates: 1830650..1830838 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: S7V914
• Locus tag: B2D07_RS07980
• Protein ID: WP_020875557.1
• Coordinates: 1830224..1830640 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B2D07_RS20355	1825435..1825596	+	162	WP_201764194.1	hypothetical protein	-
B2D07_RS20360	1825613..1825834	+	222	WP_020875551.1	hypothetical protein	-
B2D07_RS07945	1825936..1826424	+	489	WP_020875552.1	GNAT family N-acetyltransferase	-
B2D07_RS07950	1826557..1827018	+	462	WP_200809278.1	ATP-binding protein	-
B2D07_RS07955	1827038..1827250	+	213	WP_020875554.1	PH domain-containing protein	-
B2D07_RS07960	1827247..1828560	+	1314	WP_020875555.1	cation:proton antiporter	-
B2D07_RS07970	1828781..1829233	+	453	WP_078081234.1	RidA family protein	-
B2D07_RS07975	1829243..1830088	+	846	WP_020875556.1	PhzF family phenazine biosynthesis protein	-
B2D07_RS07980	1830224..1830640	-	417	WP_020875557.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
B2D07_RS07985	1830650..1830838	-	189	WP_078081235.1	type II toxin-antitoxin system HicA family toxin	Toxin
B2D07_RS07990	1830985..1832124	+	1140	WP_020875558.1	NADH:flavin oxidoreductase	-
B2D07_RS07995	1832244..1832486	+	243	WP_020875559.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
B2D07_RS08000	1832486..1832746	+	261	WP_020875560.1	Txe/YoeB family addiction module toxin	-
B2D07_RS08005	1833015..1833329	-	315	WP_020875561.1	HigA family addiction module antidote protein	-
B2D07_RS08010	1833341..1833622	-	282	WP_078081377.1	type II toxin-antitoxin system RelE/ParE family toxin	-
B2D07_RS08015	1833983..1834468	+	486	WP_020875562.1	DUF1772 domain-containing protein	-
B2D07_RS08020	1834772..1835395	+	624	WP_040414325.1	hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-125)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7153.33 Da
• Isoelectric Point: 11.0174

>T73489 WP_078081235.1 NZ_CP019913:c1830838-1830650 [Desulfococcus multivorans]
MDSRKIIQILKQNGWYEIAKVGSHTQFRHPQKKGRVTVPHPEKDIPIGTLKSIERQSGIKFT

Nucleotide

• Length: 189 bp

>T73489 NZ_CP019913:c1830838-1830650 [Desulfococcus multivorans]
ATGGACAGCCGGAAAATCATTCAGATACTCAAACAGAACGGCTGGTATGAGATCGCCAAAGTTGGCTCTCATACACAATT
CCGGCATCCACAAAAAAAGGGACGCGTAACCGTACCACACCCTGAAAAGGATATACCGATCGGCACATTAAAGAGTATCG
AGCGCCAGTCGGGAATTAAGTTCACGTGA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 14879.96 Da
• Isoelectric Point: 5.1473

>AT73489 WP_020875557.1 NZ_CP019913:c1830640-1830224 [Desulfococcus multivorans]
MANYIAVVHKASKTDFGVSFPDFPGCITAGQTVDEAKDLAQEALALHVKGMIEDGDEMPAPSKLEDIMADADYADVIAYL
VVSIPDTKPRTVRINITVPEMTLKQIDAAAKKRGMSRSSFLVHLAQNAIHSDHSQPSA

Nucleotide

• Length: 417 bp

>AT73489 NZ_CP019913:c1830640-1830224 [Desulfococcus multivorans]
ATGGCAAATTATATAGCTGTCGTTCATAAAGCGTCCAAAACTGACTTTGGCGTATCTTTTCCAGATTTTCCGGGTTGTAT
TACCGCTGGGCAAACCGTGGACGAAGCCAAGGATTTAGCCCAAGAGGCGCTTGCACTCCATGTTAAAGGAATGATTGAAG
ACGGCGATGAAATGCCGGCTCCATCCAAACTCGAAGATATAATGGCTGATGCGGACTACGCTGATGTCATCGCTTATCTG
GTAGTTTCTATTCCGGATACCAAACCTCGCACCGTAAGGATCAATATTACCGTGCCAGAGATGACCCTTAAGCAAATTGA
TGCAGCAGCCAAAAAAAGGGGAATGTCAAGATCCTCCTTTCTCGTTCATCTCGCGCAGAACGCGATTCATTCAGATCATT
CTCAACCATCGGCATAG

Structures

Antitoxin

• AlphaFold DB: S7V914