Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1830224..1830838 | Replicon | chromosome |
| Accession | NZ_CP019913 | ||
| Organism | Desulfococcus multivorans strain DSM 2059 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | B2D07_RS07985 | Protein ID | WP_078081235.1 |
| Coordinates | 1830650..1830838 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | S7V914 |
| Locus tag | B2D07_RS07980 | Protein ID | WP_020875557.1 |
| Coordinates | 1830224..1830640 (-) | Length | 139 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| B2D07_RS20355 | 1825435..1825596 | + | 162 | WP_201764194.1 | hypothetical protein | - |
| B2D07_RS20360 | 1825613..1825834 | + | 222 | WP_020875551.1 | hypothetical protein | - |
| B2D07_RS07945 | 1825936..1826424 | + | 489 | WP_020875552.1 | GNAT family N-acetyltransferase | - |
| B2D07_RS07950 | 1826557..1827018 | + | 462 | WP_200809278.1 | ATP-binding protein | - |
| B2D07_RS07955 | 1827038..1827250 | + | 213 | WP_020875554.1 | PH domain-containing protein | - |
| B2D07_RS07960 | 1827247..1828560 | + | 1314 | WP_020875555.1 | cation:proton antiporter | - |
| B2D07_RS07970 | 1828781..1829233 | + | 453 | WP_078081234.1 | RidA family protein | - |
| B2D07_RS07975 | 1829243..1830088 | + | 846 | WP_020875556.1 | PhzF family phenazine biosynthesis protein | - |
| B2D07_RS07980 | 1830224..1830640 | - | 417 | WP_020875557.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| B2D07_RS07985 | 1830650..1830838 | - | 189 | WP_078081235.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| B2D07_RS07990 | 1830985..1832124 | + | 1140 | WP_020875558.1 | NADH:flavin oxidoreductase | - |
| B2D07_RS07995 | 1832244..1832486 | + | 243 | WP_020875559.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| B2D07_RS08000 | 1832486..1832746 | + | 261 | WP_020875560.1 | Txe/YoeB family addiction module toxin | - |
| B2D07_RS08005 | 1833015..1833329 | - | 315 | WP_020875561.1 | HigA family addiction module antidote protein | - |
| B2D07_RS08010 | 1833341..1833622 | - | 282 | WP_078081377.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| B2D07_RS08015 | 1833983..1834468 | + | 486 | WP_020875562.1 | DUF1772 domain-containing protein | - |
| B2D07_RS08020 | 1834772..1835395 | + | 624 | WP_040414325.1 | hydrolase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7153.33 Da Isoelectric Point: 11.0174
>T73489 WP_078081235.1 NZ_CP019913:c1830838-1830650 [Desulfococcus multivorans]
MDSRKIIQILKQNGWYEIAKVGSHTQFRHPQKKGRVTVPHPEKDIPIGTLKSIERQSGIKFT
MDSRKIIQILKQNGWYEIAKVGSHTQFRHPQKKGRVTVPHPEKDIPIGTLKSIERQSGIKFT
Download Length: 189 bp
>T73489 NZ_CP019913:c1830838-1830650 [Desulfococcus multivorans]
ATGGACAGCCGGAAAATCATTCAGATACTCAAACAGAACGGCTGGTATGAGATCGCCAAAGTTGGCTCTCATACACAATT
CCGGCATCCACAAAAAAAGGGACGCGTAACCGTACCACACCCTGAAAAGGATATACCGATCGGCACATTAAAGAGTATCG
AGCGCCAGTCGGGAATTAAGTTCACGTGA
ATGGACAGCCGGAAAATCATTCAGATACTCAAACAGAACGGCTGGTATGAGATCGCCAAAGTTGGCTCTCATACACAATT
CCGGCATCCACAAAAAAAGGGACGCGTAACCGTACCACACCCTGAAAAGGATATACCGATCGGCACATTAAAGAGTATCG
AGCGCCAGTCGGGAATTAAGTTCACGTGA
Antitoxin
Download Length: 139 a.a. Molecular weight: 14879.96 Da Isoelectric Point: 5.1473
>AT73489 WP_020875557.1 NZ_CP019913:c1830640-1830224 [Desulfococcus multivorans]
MANYIAVVHKASKTDFGVSFPDFPGCITAGQTVDEAKDLAQEALALHVKGMIEDGDEMPAPSKLEDIMADADYADVIAYL
VVSIPDTKPRTVRINITVPEMTLKQIDAAAKKRGMSRSSFLVHLAQNAIHSDHSQPSA
MANYIAVVHKASKTDFGVSFPDFPGCITAGQTVDEAKDLAQEALALHVKGMIEDGDEMPAPSKLEDIMADADYADVIAYL
VVSIPDTKPRTVRINITVPEMTLKQIDAAAKKRGMSRSSFLVHLAQNAIHSDHSQPSA
Download Length: 417 bp
>AT73489 NZ_CP019913:c1830640-1830224 [Desulfococcus multivorans]
ATGGCAAATTATATAGCTGTCGTTCATAAAGCGTCCAAAACTGACTTTGGCGTATCTTTTCCAGATTTTCCGGGTTGTAT
TACCGCTGGGCAAACCGTGGACGAAGCCAAGGATTTAGCCCAAGAGGCGCTTGCACTCCATGTTAAAGGAATGATTGAAG
ACGGCGATGAAATGCCGGCTCCATCCAAACTCGAAGATATAATGGCTGATGCGGACTACGCTGATGTCATCGCTTATCTG
GTAGTTTCTATTCCGGATACCAAACCTCGCACCGTAAGGATCAATATTACCGTGCCAGAGATGACCCTTAAGCAAATTGA
TGCAGCAGCCAAAAAAAGGGGAATGTCAAGATCCTCCTTTCTCGTTCATCTCGCGCAGAACGCGATTCATTCAGATCATT
CTCAACCATCGGCATAG
ATGGCAAATTATATAGCTGTCGTTCATAAAGCGTCCAAAACTGACTTTGGCGTATCTTTTCCAGATTTTCCGGGTTGTAT
TACCGCTGGGCAAACCGTGGACGAAGCCAAGGATTTAGCCCAAGAGGCGCTTGCACTCCATGTTAAAGGAATGATTGAAG
ACGGCGATGAAATGCCGGCTCCATCCAAACTCGAAGATATAATGGCTGATGCGGACTACGCTGATGTCATCGCTTATCTG
GTAGTTTCTATTCCGGATACCAAACCTCGCACCGTAAGGATCAATATTACCGTGCCAGAGATGACCCTTAAGCAAATTGA
TGCAGCAGCCAAAAAAAGGGGAATGTCAAGATCCTCCTTTCTCGTTCATCTCGCGCAGAACGCGATTCATTCAGATCATT
CTCAACCATCGGCATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|