Detailed information of TA system TA073488

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-UPF0150
• Location: 492071..492504
• Replicon: chromosome
• Accession: NZ_CP019913
• Organism: Desulfococcus multivorans strain DSM 2059

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: B2D07_RS02110
• Protein ID: WP_078081173.1
• Coordinates: 492280..492504 (+)
• Length: 75 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: B2D07_RS02105
• Protein ID: WP_040416853.1
• Coordinates: 492071..492283 (+)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B2D07_RS19700	490362..490559	+	198	WP_040416847.1	hypothetical protein	-
B2D07_RS02095	490652..490906	+	255	WP_078081172.1	type II toxin-antitoxin system HicB family antitoxin	-
B2D07_RS02100	491029..491868	+	840	WP_040416850.1	class I SAM-dependent methyltransferase	-
B2D07_RS02105	492071..492283	+	213	WP_040416853.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
B2D07_RS02110	492280..492504	+	225	WP_078081173.1	type II toxin-antitoxin system HicA family toxin	Toxin
B2D07_RS02115	492635..492823	+	189	WP_020878760.1	hypothetical protein	-
B2D07_RS02120	492842..493612	+	771	WP_020878761.1	MBL fold metallo-hydrolase	-
B2D07_RS02125	494376..494639	+	264	WP_020878762.1	hypothetical protein	-
B2D07_RS02130	494830..496410	-	1581	WP_020878763.1	phospholipase D family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (10-65)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-60)

Sequences

Toxin

Protein

• Length: 75 a.a.
• Molecular weight: 8017.40 Da
• Isoelectric Point: 11.2875

>T73488 WP_078081173.1 NZ_CP019913:492280-492504 [Desulfococcus multivorans]
VSKLPKISGKAAVSALSKIGYGIDHQTGSHMILRQSAPPNRRLTIPNHKELATGTLRAIIRQAGLTVEEFMNLL

Nucleotide

• Length: 225 bp

>T73488 NZ_CP019913:492280-492504 [Desulfococcus multivorans]
GTGAGCAAGCTACCCAAAATATCCGGAAAAGCAGCGGTGTCTGCATTGTCAAAAATCGGATATGGAATCGATCATCAAAC
AGGAAGCCACATGATACTTAGGCAATCTGCTCCGCCAAATCGACGGCTCACAATACCCAATCACAAAGAATTGGCAACAG
GTACACTACGGGCAATAATCAGGCAAGCTGGGTTAACAGTCGAAGAGTTCATGAATCTGCTTTGA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7745.90 Da
• Isoelectric Point: 4.1364

>AT73488 WP_040416853.1 NZ_CP019913:492071-492283 [Desulfococcus multivorans]
MKFRIIIEQDEDGMFVAEVPALPGCISQGTTREESLTNIKDAIIGYLESLKKHGDPIPPSIYEEVIEVAV

Nucleotide

• Length: 213 bp

>AT73488 NZ_CP019913:492071-492283 [Desulfococcus multivorans]
ATGAAGTTTAGAATTATTATTGAACAAGATGAAGATGGGATGTTTGTGGCTGAAGTTCCTGCCTTGCCGGGTTGTATTTC
CCAAGGCACCACGCGAGAAGAATCGCTTACAAATATAAAAGATGCCATTATCGGATATTTGGAAAGTTTGAAAAAGCATG
GAGATCCGATACCCCCGTCAATATACGAAGAGGTAATCGAGGTAGCGGTGTGA