Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2167216..2168014 Replicon chromosome
Accession NZ_CP019903
Organism Escherichia coli strain MDR_56

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VRA6
Locus tag B1200_RS11225 Protein ID WP_000854730.1
Coordinates 2167216..2167593 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P0SQV8
Locus tag B1200_RS11230 Protein ID WP_001285481.1
Coordinates 2167640..2168014 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B1200_RS11195 2163250..2163541 + 292 Protein_2021 transposase -
B1200_RS11200 2163538..2163888 + 351 WP_000624707.1 IS66 family insertion sequence element accessory protein TnpB -
B1200_RS11205 2163919..2165512 + 1594 Protein_2023 IS66 family transposase -
B1200_RS11215 2165660..2166648 + 989 Protein_2024 IS630 family transposase -
B1200_RS11220 2166727..2167219 - 493 Protein_2025 hypothetical protein -
B1200_RS11225 2167216..2167593 - 378 WP_000854730.1 TA system toxin CbtA family protein Toxin
B1200_RS11230 2167640..2168014 - 375 WP_001285481.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
B1200_RS11235 2168064..2168708 - 645 WP_000086759.1 hypothetical protein -
B1200_RS11240 2168727..2168948 - 222 WP_000692315.1 DUF987 domain-containing protein -
B1200_RS11245 2169011..2169487 - 477 WP_001313574.1 RadC family protein -
B1200_RS11250 2169503..2169976 - 474 WP_001313575.1 antirestriction protein -
B1200_RS11255 2170070..2170315 - 246 WP_001164966.1 hypothetical protein -
B1200_RS11260 2170315..2171136 - 822 WP_001234359.1 DUF945 domain-containing protein -
B1200_RS11265 2171158..2172366 - 1209 WP_001352368.1 IS4-like element ISVsa5 family transposase -
B1200_RS11275 2172574..2172807 - 234 WP_001213776.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2162075..2187117 25042
- inside IScluster/Tn - - 2163250..2181073 17823


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14212.21 Da        Isoelectric Point: 7.2923

>T73451 WP_000854730.1 NZ_CP019903:c2167593-2167216 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 378 bp

>T73451 NZ_CP019903:c2167593-2167216 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCTTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CAACTACAGAATGGTGAACGACATCATCCGGGGTGAACATTCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13817.53 Da        Isoelectric Point: 4.7511

>AT73451 WP_001285481.1 NZ_CP019903:c2168014-2167640 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT73451 NZ_CP019903:c2168014-2167640 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCATCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V671

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0SQV8

References