Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1571136..1571934 Replicon chromosome
Accession NZ_CP019903
Organism Escherichia coli strain MDR_56

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag B1200_RS08145 Protein ID WP_000854735.1
Coordinates 1571136..1571513 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A067H947
Locus tag B1200_RS08150 Protein ID WP_001285415.1
Coordinates 1571560..1571934 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B1200_RS08110 1566412..1567950 - 1539 WP_001187195.1 lysine decarboxylation/transport transcriptional activator CadC -
B1200_RS08120 1568833..1569159 - 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
B1200_RS08125 1569156..1569419 - 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
B1200_RS08130 1569491..1570357 - 867 WP_001280433.1 DUF4942 domain-containing protein -
B1200_RS08135 1570442..1570639 - 198 WP_000839291.1 DUF957 domain-containing protein -
B1200_RS08140 1570651..1571139 - 489 WP_000761676.1 hypothetical protein -
B1200_RS08145 1571136..1571513 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
B1200_RS08150 1571560..1571934 - 375 WP_001285415.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
B1200_RS08155 1572014..1572235 - 222 WP_000692309.1 DUF987 domain-containing protein -
B1200_RS08160 1572298..1572774 - 477 WP_001366855.1 RadC family protein -
B1200_RS08165 1572790..1573269 - 480 WP_000844100.1 antirestriction protein -
B1200_RS08170 1573351..1574169 - 819 WP_001175148.1 DUF945 domain-containing protein -
B1200_RS08175 1574259..1574492 - 234 WP_001278287.1 DUF905 family protein -
B1200_RS08180 1574498..1575175 - 678 WP_001097302.1 hypothetical protein -
B1200_RS08185 1575323..1576003 - 681 Protein_1466 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T73448 WP_000854735.1 NZ_CP019903:c1571513-1571136 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T73448 NZ_CP019903:c1571513-1571136 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13663.32 Da        Isoelectric Point: 5.8640

>AT73448 WP_001285415.1 NZ_CP019903:c1571934-1571560 [Escherichia coli]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT73448 NZ_CP019903:c1571934-1571560 [Escherichia coli]
GTGTCAGACACACACCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A067H947

References