Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1693268..1693923 Replicon chromosome
Accession NZ_CP019894
Organism Neisseria lactamica strain Y92-1009

Toxin (Protein)


Gene name vapC Uniprot ID A0A1V0DVF8
Locus tag B2G52_RS09225 Protein ID WP_003712355.1
Coordinates 1693268..1693687 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID E4ZDN9
Locus tag B2G52_RS09230 Protein ID WP_003712357.1
Coordinates 1693684..1693923 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B2G52_RS09205 1688501..1689907 - 1407 WP_003712349.1 MFS transporter -
B2G52_RS12015 1689949..1690152 + 204 WP_153063755.1 hypothetical protein -
B2G52_RS09210 1690191..1690970 + 780 WP_003712351.1 (Fe-S)-binding protein -
B2G52_RS09215 1690967..1691668 + 702 WP_003712352.1 lactate utilization protein C -
B2G52_RS09220 1691665..1693119 + 1455 WP_003712354.1 iron-sulfur cluster-binding protein -
B2G52_RS09225 1693268..1693687 - 420 WP_003712355.1 type II toxin-antitoxin system VapC family toxin Toxin
B2G52_RS09230 1693684..1693923 - 240 WP_003712357.1 hypothetical protein Antitoxin
B2G52_RS09235 1694178..1694621 + 444 WP_003712358.1 DNA cytosine methyltransferase -
B2G52_RS09245 1694738..1695223 - 486 WP_003712359.1 5-(carboxyamino)imidazole ribonucleotide mutase -
B2G52_RS09250 1695273..1695986 - 714 WP_003712360.1 tol-pal system YbgF family protein -
B2G52_RS09255 1695986..1696654 - 669 WP_003712361.1 O-methyltransferase -
B2G52_RS09260 1696665..1696850 - 186 WP_002216929.1 DUF3460 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15189.59 Da        Isoelectric Point: 5.9688

>T73434 WP_003712355.1 NZ_CP019894:c1693687-1693268 [Neisseria lactamica]
MILLDTNVISEPLRPQPDAHVVAWLDSLMLEDVYLSAMTVAELRLGVALLPDGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIHSYAKTHGKAIAAADGYIAATAKQHRLAVATRDTGPFFAADVAVFNPWCD

Download         Length: 420 bp

>T73434 NZ_CP019894:c1693687-1693268 [Neisseria lactamica]
ATGATTTTACTGGATACGAATGTGATTTCCGAACCTTTGCGCCCGCAGCCTGATGCGCATGTGGTGGCATGGTTGGATAG
TCTTATGTTAGAAGATGTGTATTTGTCTGCCATGACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCCTGATGGTA
AGAAAAAGAATGTGCTGCACGAGCGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATATATGCGCAAATTCATTCCTATGCCAAAACACATGGCAAAGCGATTGCCGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACCGTTTGGCAGTTGCTACGCGTGATACCGGTCCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGTGCGATTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8673.83 Da        Isoelectric Point: 8.9167

>AT73434 WP_003712357.1 NZ_CP019894:c1693923-1693684 [Neisseria lactamica]
MASVVIRNLSETTHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEVDGVELDNVRDFDTKNRVSFG

Download         Length: 240 bp

>AT73434 NZ_CP019894:c1693923-1693684 [Neisseria lactamica]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGACCACGCACAACGCAATCAAATTCCGCGCGCGAGCCGCAGGGCGCAG
TACCGAAGCGGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACGGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAGTGGATGGTGTGGAGTTGGATAACGTGCGTGATTTCGATACCAAGAACAGGGTATCCTTTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1V0DVF8

Antitoxin

Source ID Structure
AlphaFold DB A0A1V0DVG7

References