73433

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 1239763..1240226 Replicon chromosome
Accession NZ_CP019894
Organism Neisseria lactamica strain Y92-1009

Toxin (Protein)


Gene name VapD Uniprot ID A0A1V0DUG4
Locus tag B2G52_RS06990 Protein ID WP_003712170.1
Coordinates 1239948..1240226 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q51002
Locus tag B2G52_RS06985 Protein ID WP_003690223.1
Coordinates 1239763..1239948 (+) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B2G52_RS06945 1235422..1236786 - 1365 WP_118779820.1 Fic family protein -
B2G52_RS06955 1237207..1237569 + 363 WP_025461592.1 transposase -
B2G52_RS06975 1239028..1239465 + 438 WP_078835943.1 VapD -
B2G52_RS06985 1239763..1239948 + 186 WP_003690223.1 DUF5397 family protein Antitoxin
B2G52_RS06990 1239948..1240226 + 279 WP_003712170.1 virulence factor Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(2-60)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10446.86 Da        Isoelectric Point: 6.9726

>T73433 WP_003712170.1 NZ_CP019894:1239948-1240226 [Neisseria lactamica]
MYAISFDLVVADTAQNHPKGISQAYADIGYTLRKFGFTRVQGSLYTCQNEDMATLFSAINELKALPWFPSSVRDIRAFRI
EQWSDFTSLVKS

Download         Length: 279 bp

>T73433 NZ_CP019894:1239948-1240226 [Neisseria lactamica]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCTTGCGGAAATTCGGTTTTACCCGCGTTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
CCCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCCGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6717.54 Da        Isoelectric Point: 4.2641

>AT73433 WP_003690223.1 NZ_CP019894:1239763-1239948 [Neisseria lactamica]
MQTTIPTGSIRTFGDYGVMYIVGTPAEQLPDGDWLVNIELPESGEHTQYKLSHIVQDPKAA

Download         Length: 186 bp

>AT73433 NZ_CP019894:1239763-1239948 [Neisseria lactamica]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCTGACGGCGATTGGCTCGTAAATATCGAGCTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1V0DUG4

Antitoxin

Source ID Structure
AlphaFold DB Q51002

References