Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3883453..3884110 Replicon chromosome
Accession NZ_CP019889
Organism Enterobacter hormaechei strain FRM

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag B1023_RS19095 Protein ID WP_017382887.1
Coordinates 3883453..3883863 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag B1023_RS19100 Protein ID WP_003863437.1
Coordinates 3883844..3884110 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B1023_RS19075 3879455..3881184 - 1730 Protein_3633 single-stranded-DNA-specific exonuclease RecJ -
B1023_RS19080 3881190..3881903 - 714 WP_045348035.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
B1023_RS19085 3881932..3882828 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
B1023_RS19090 3882930..3883451 + 522 WP_015571793.1 flavodoxin FldB -
B1023_RS19095 3883453..3883863 - 411 WP_017382887.1 protein YgfX Toxin
B1023_RS19100 3883844..3884110 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
B1023_RS19105 3884405..3885385 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
B1023_RS19110 3885497..3886156 - 660 WP_003863433.1 hemolysin III family protein -
B1023_RS19115 3886423..3887154 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
B1023_RS19120 3887271..3888704 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T73430 WP_017382887.1 NZ_CP019889:c3883863-3883453 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T73430 NZ_CP019889:c3883863-3883453 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT73430 WP_003863437.1 NZ_CP019889:c3884110-3883844 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT73430 NZ_CP019889:c3884110-3883844 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References