Detailed information of TA system TA073421

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2097870..2098481
• Replicon: chromosome
• Accession: NZ_CP019889
• Organism: Enterobacter hormaechei strain FRM

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: D2TUP9
• Locus tag: B1023_RS10505
• Protein ID: WP_012906750.1
• Coordinates: 2098302..2098481 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: B1023_RS10500
• Protein ID: WP_047737705.1
• Coordinates: 2097870..2098280 (-)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B1023_RS10480	2093679..2094230	+	552	WP_023299876.1	phage tail protein I	-
B1023_RS10485	2094233..2094910	+	678	Protein_1986	phage tail protein	-
B1023_RS10490	2096796..2097218	+	423	WP_047737699.1	tail fiber assembly protein	-
B1023_RS10495	2097222..2097788	-	567	WP_047737702.1	serine acetyltransferase	-
B1023_RS10500	2097870..2098280	-	411	WP_047737705.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
B1023_RS10505	2098302..2098481	-	180	WP_012906750.1	type II toxin-antitoxin system HicA family toxin	Toxin
B1023_RS10510	2098966..2099562	-	597	WP_047737708.1	Rha family transcriptional regulator	-
B1023_RS25805	2099474..2099853	-	380	Protein_1992	ash family protein	-
B1023_RS10515	2100249..2101175	+	927	WP_045348698.1	LysR family transcriptional regulator	-
B1023_RS10520	2101181..2101651	-	471	WP_045348696.1	hypothetical protein	-
B1023_RS10525	2101817..2102533	-	717	WP_017384431.1	ABC transporter ATP-binding protein	-
B1023_RS10530	2102530..2103405	-	876	WP_015570244.1	ATP-binding cassette domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	gtrB / gtrA / fliA	1991285..2102521	111236

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6644.85 Da
• Isoelectric Point: 10.9132

>T73421 WP_012906750.1 NZ_CP019889:c2098481-2098302 [Enterobacter hormaechei]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Nucleotide

• Length: 180 bp

>T73421 NZ_CP019889:c2098481-2098302 [Enterobacter hormaechei]
ATGGATAGCAGGAATGCAATAGCAATGATAGAAGCCGATGGGTGGTATCTGGTGAGAGTAAAAGGCAGTCATCACCAGTT
CAAACACCCAACGAAAAAGGGGCTGGTGACGGTAAAGCATCCACAGAAAGACATACCGTTACCAACACTGAAAAGCATAA
AAAAACAGGCGGGGCTCTAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14874.84 Da
• Isoelectric Point: 4.3793

>AT73421 WP_047737705.1 NZ_CP019889:c2098280-2097870 [Enterobacter hormaechei]
MLYPVAIDKGVSSFGVRVPDIPGCFSGGDDYQDAIESVREAIEAHIELLVEDGESVPEATTVENWLSDPEYAGAVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR

Nucleotide

• Length: 411 bp

>AT73421 NZ_CP019889:c2098280-2097870 [Enterobacter hormaechei]
ATGTTGTACCCTGTTGCTATTGATAAAGGCGTTTCATCCTTCGGCGTTCGCGTACCTGATATTCCTGGCTGCTTCTCTGG
CGGTGATGATTATCAGGACGCGATTGAAAGCGTACGTGAAGCGATCGAGGCTCACATCGAATTACTGGTTGAAGATGGCG
AGAGCGTTCCAGAAGCAACGACCGTCGAAAACTGGCTTTCTGATCCGGAGTACGCCGGTGCGGTCTGGGCCTTGGTAGAC
GTGGATATAACACGCCTGATGGGAAAAGCGGAAAAAATTAATGTGACGCTTCCCTCATTGCTGATCCGTCGTATCGATCA
GTTCGTGGCCGCGCATCCAGAATACGGCAGTCGGTCTGGCTTCCTGTCTCGTGTCGCGGCAGACAAAGTAATTGGACGAG
AAAAACGATAA

Structures

Toxin

• AlphaFold DB: A0A7D6XDK4