Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4475108..4475730 Replicon chromosome
Accession NZ_CP019871
Organism Pseudomonas syringae pv. tomato strain B13-200

Toxin (Protein)


Gene name hicA Uniprot ID Q886E5
Locus tag XJ28_RS21690 Protein ID WP_011103638.1
Coordinates 4475548..4475730 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q886E4
Locus tag XJ28_RS21685 Protein ID WP_005767619.1
Coordinates 4475108..4475512 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XJ28_RS21670 4470878..4471546 + 669 WP_007245682.1 ABC transporter ATP-binding protein -
XJ28_RS21675 4471546..4474023 + 2478 WP_010202744.1 ABC transporter permease -
XJ28_RS21680 4474013..4475092 + 1080 WP_010202739.1 iron ABC transporter permease -
XJ28_RS21685 4475108..4475512 - 405 WP_005767619.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
XJ28_RS21690 4475548..4475730 - 183 WP_011103638.1 type II toxin-antitoxin system HicA family toxin Toxin
XJ28_RS21695 4476015..4477787 + 1773 WP_007245686.1 N-acetylglutaminylglutamine amidotransferase -
XJ28_RS21700 4477791..4479539 + 1749 WP_005767614.1 N-acetylglutaminylglutamine synthetase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6675.81 Da        Isoelectric Point: 10.6643

>T73404 WP_011103638.1 NZ_CP019871:c4475730-4475548 [Pseudomonas syringae pv. tomato]
VQSRQLVKELEADGWVLDRVTGSHHMFKHPEKSQTVPVPHPKKDLPLGTVKAIRKLAGLA

Download         Length: 183 bp

>T73404 NZ_CP019871:c4475730-4475548 [Pseudomonas syringae pv. tomato]
GTGCAAAGCAGGCAATTGGTAAAGGAGCTTGAAGCAGATGGTTGGGTTCTTGATCGTGTCACCGGCAGTCACCATATGTT
CAAACACCCAGAAAAGTCTCAAACAGTTCCGGTGCCGCATCCCAAGAAAGACTTGCCGCTTGGAACAGTAAAGGCCATCA
GAAAGCTTGCCGGATTGGCGTAG

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14455.52 Da        Isoelectric Point: 4.9093

>AT73404 WP_005767619.1 NZ_CP019871:c4475512-4475108 [Pseudomonas syringae pv. tomato]
MKYPICIEWGDETTAFGIQIPDIPGAITAGDTFEEAHAAAVEIAHIMLQEIAASGGSIPKVGTVAEHAKNPDFSGMGWGM
LEIDVTPYLGKTEKVNVTLPGFVIRQIDRYVRDHSIKSRSTFLADAALEKLGRA

Download         Length: 405 bp

>AT73404 NZ_CP019871:c4475512-4475108 [Pseudomonas syringae pv. tomato]
ATGAAATATCCAATATGCATAGAGTGGGGCGATGAGACCACAGCGTTCGGCATTCAGATACCGGACATACCTGGTGCTAT
CACCGCAGGCGATACCTTTGAGGAGGCTCATGCGGCAGCCGTTGAGATCGCTCATATCATGCTGCAGGAGATTGCAGCCA
GTGGCGGGTCTATTCCGAAAGTCGGGACCGTTGCCGAGCATGCCAAAAACCCTGATTTTTCTGGAATGGGCTGGGGCATG
CTGGAAATCGATGTAACGCCTTATCTAGGCAAGACGGAAAAGGTCAACGTCACCTTGCCTGGCTTTGTGATCAGACAGAT
CGACCGCTACGTAAGGGATCACAGCATCAAAAGTCGCTCGACCTTCCTGGCTGATGCTGCGCTGGAAAAGCTCGGTCGAG
CGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q886E5

Antitoxin

Source ID Structure
AlphaFold DB A0A3M3Z2W9

References