Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 6497158..6498698 Replicon chromosome
Accession NZ_CP019856
Organism Pseudomonas azotoformans strain F77

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag B1R45_RS29960 Protein ID WP_078051009.1
Coordinates 6497424..6498698 (-) Length 425 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag B1R45_RS29955 Protein ID WP_078050791.1
Coordinates 6497158..6497427 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B1R45_RS29935 6493547..6495094 - 1548 WP_078050787.1 PLP-dependent aminotransferase family protein -
B1R45_RS29940 6495182..6495820 + 639 WP_078050788.1 FMN-binding negative transcriptional regulator -
B1R45_RS29945 6495817..6496263 + 447 WP_078050789.1 GNAT family N-acetyltransferase -
B1R45_RS29950 6496274..6496945 + 672 WP_078050790.1 GNAT family N-acetyltransferase -
B1R45_RS29955 6497158..6497427 - 270 WP_078050791.1 helix-turn-helix domain-containing protein Antitoxin
B1R45_RS29960 6497424..6498698 - 1275 WP_078051009.1 HipA domain-containing protein Toxin
B1R45_RS29965 6499050..6500324 + 1275 WP_078050792.1 autotransporter outer membrane beta-barrel domain-containing protein -
B1R45_RS29970 6500414..6502222 - 1809 WP_078050793.1 sodium-extruding oxaloacetate decarboxylase subunit alpha -
B1R45_RS29975 6502234..6503649 - 1416 WP_003195732.1 acetyl-CoA carboxylase biotin carboxylase subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-349)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-82)


Sequences

Toxin        


Download         Length: 425 a.a.        Molecular weight: 47125.44 Da        Isoelectric Point: 5.5952

>T73337 WP_078051009.1 NZ_CP019856:c6498698-6497424 [Pseudomonas azotoformans]
MTLEFSEPDKGFASPCRFGYESDYLVDHLDHIDTVFAKAVSVRVPLNWAQEAPRNAPAFLHDIAPAGAAKRFLASRFEML
STDNVSSDLFLLARSTPAPIGHMRIKESLQALNDRPPMGFERQEVIDRDNRFLEYAYEQGAAIGGATGAGGEAPKLLLTQ
SHEGLLYPDAVLGDDQASQHWFIKFARNQGLQIDQDILRSEFHYYKALQSLGIETVAVEGLALEMATKPSLWMHRFDRHV
SDQGVERFAVESIYSLAGVTKPGSAMSHLDVLLQLAGLWQQAGQGEQLTDLVADYLRRDLLNKVLGNSDNHGRNTSIIRG
PDSLRLAPIYDLAPMVMDPEGVTRTTKWPRPLEIAGDIDWRGVCNALAPVINPTDAFERLRTDAQRLRALPDILVDSGLP
KVTLNHPSIALRNLDQRLRSWGLQ

Download         Length: 1275 bp

>T73337 NZ_CP019856:c6498698-6497424 [Pseudomonas azotoformans]
ATGACGCTTGAGTTTTCAGAGCCGGATAAAGGTTTCGCAAGCCCCTGCCGTTTCGGCTACGAGTCTGATTACCTGGTTGA
TCATTTGGACCATATTGACACTGTGTTTGCCAAGGCCGTGAGTGTAAGGGTGCCCTTGAACTGGGCGCAGGAGGCTCCCC
GGAACGCCCCGGCCTTTCTTCATGACATCGCACCTGCGGGTGCAGCGAAGCGGTTCCTGGCTAGCCGCTTTGAGATGCTG
AGCACTGATAACGTCAGTTCGGATTTGTTTTTGTTAGCGCGAAGCACTCCTGCCCCTATCGGACACATGCGAATCAAGGA
GTCACTTCAGGCCCTCAACGACCGTCCACCTATGGGCTTTGAACGACAGGAGGTGATTGATCGCGATAACCGATTTCTGG
AGTACGCCTACGAGCAGGGGGCTGCTATTGGGGGAGCGACCGGCGCAGGTGGAGAGGCCCCAAAGCTGTTGTTGACGCAA
AGCCACGAAGGCTTGCTTTATCCAGATGCGGTGTTGGGTGATGATCAAGCCAGCCAGCACTGGTTTATAAAGTTTGCTCG
TAATCAAGGCCTGCAGATTGATCAAGACATTCTGAGAAGCGAATTTCACTACTACAAAGCGCTGCAGTCATTAGGGATCG
AGACCGTTGCAGTCGAGGGCCTGGCGTTGGAGATGGCGACAAAGCCAAGTCTTTGGATGCACCGTTTTGATCGTCATGTC
AGTGATCAAGGAGTGGAGCGCTTTGCGGTGGAGTCCATTTATTCTCTGGCAGGTGTAACAAAACCGGGCAGCGCGATGAG
CCATCTGGATGTGTTGTTGCAACTGGCAGGTTTGTGGCAGCAGGCAGGTCAAGGTGAACAATTGACCGACTTGGTCGCGG
ATTATCTTCGTCGCGACTTGCTCAATAAAGTGTTGGGGAATTCCGACAACCATGGGCGGAACACATCGATTATTCGTGGC
CCCGATAGCTTGCGTCTGGCCCCCATCTACGACCTCGCACCGATGGTCATGGACCCTGAAGGTGTTACTCGCACGACTAA
GTGGCCGCGGCCCCTGGAAATCGCGGGTGATATTGATTGGCGCGGTGTATGTAATGCGCTCGCACCGGTTATTAACCCCA
CGGATGCCTTTGAGCGCTTACGCACAGATGCTCAGCGTCTCAGGGCGCTGCCGGATATATTGGTCGACAGTGGTTTACCG
AAGGTCACCTTGAATCATCCGAGTATTGCCTTACGAAACCTTGATCAGCGTCTGAGAAGTTGGGGCCTCCAATGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9877.51 Da        Isoelectric Point: 10.9066

>AT73337 WP_078050791.1 NZ_CP019856:c6497427-6497158 [Pseudomonas azotoformans]
MSLSMSQRAQVIESIEQGLSDGSLEIGDAVRRLRTEVTGLHQAQFAKMCKISVRTLVHIEHGEGNQTLKSLNAVFRPFGL
KMGVVKVRR

Download         Length: 270 bp

>AT73337 NZ_CP019856:c6497427-6497158 [Pseudomonas azotoformans]
ATGAGCCTCTCGATGAGTCAGCGCGCGCAAGTGATTGAAAGCATCGAGCAGGGCTTGTCAGACGGTTCTCTCGAAATAGG
CGACGCTGTGCGCCGTCTACGCACCGAAGTCACTGGCCTGCACCAAGCCCAGTTCGCCAAGATGTGCAAAATCTCTGTGC
GCACGTTGGTGCATATTGAACATGGCGAAGGGAATCAGACGCTTAAGTCACTGAATGCCGTGTTCAGGCCGTTTGGACTG
AAGATGGGCGTGGTCAAGGTCCGCCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References