Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3730238..3730858 Replicon chromosome
Accession NZ_CP019839
Organism Enterobacter roggenkampii strain R11

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag B1H21_RS18060 Protein ID WP_008499287.1
Coordinates 3730640..3730858 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag B1H21_RS18055 Protein ID WP_008499288.1
Coordinates 3730238..3730612 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B1H21_RS18045 3725366..3726559 + 1194 WP_021241633.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
B1H21_RS18050 3726582..3729728 + 3147 WP_008499289.1 multidrug efflux RND transporter permease subunit -
B1H21_RS18055 3730238..3730612 + 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
B1H21_RS18060 3730640..3730858 + 219 WP_008499287.1 hemolysin expression modulator Hha Toxin
B1H21_RS18065 3731065..3731616 + 552 WP_021241634.1 maltose O-acetyltransferase -
B1H21_RS18070 3731734..3732201 + 468 WP_008499285.1 membrane protein -
B1H21_RS18075 3732173..3733633 - 1461 WP_063418458.1 PLP-dependent aminotransferase family protein -
B1H21_RS18080 3733735..3734445 + 711 WP_063418459.1 GNAT family N-acetyltransferase -
B1H21_RS18085 3734442..3734582 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
B1H21_RS18090 3734585..3734845 - 261 WP_006176933.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T73331 WP_008499287.1 NZ_CP019839:3730640-3730858 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T73331 NZ_CP019839:3730640-3730858 [Enterobacter roggenkampii]
ATGTCTGATAAACCACTCACTAAAATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACCCTCGAACGCGT
GATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCCGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAGC
TGACCATGAATAAGTTGTATGACAAAATCCCTACTTCTGTATGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT73331 WP_008499288.1 NZ_CP019839:3730238-3730612 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT73331 NZ_CP019839:3730238-3730612 [Enterobacter roggenkampii]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAACCTTGATGAAAGCAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGTAGTTACGGCATTAACGCCCAGGATTTGCAAAAATGGCGTAAATCGGGAAACCGGCT
ATTCCGCTGTTTTGTCAACGTGAGCAGAGCTAACCCGGTTAGCCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References