Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 845512..846169 Replicon chromosome
Accession NZ_CP019839
Organism Enterobacter roggenkampii strain R11

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag B1H21_RS04160 Protein ID WP_021242050.1
Coordinates 845759..846169 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag B1H21_RS04155 Protein ID WP_006178375.1
Coordinates 845512..845778 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B1H21_RS04135 840946..842379 - 1434 WP_023294510.1 6-phospho-beta-glucosidase BglA -
B1H21_RS04140 842496..843227 - 732 WP_021242053.1 MurR/RpiR family transcriptional regulator -
B1H21_RS04145 843493..844152 + 660 WP_008499713.1 hemolysin III family protein -
B1H21_RS04150 844237..845217 - 981 WP_063418236.1 tRNA-modifying protein YgfZ -
B1H21_RS04155 845512..845778 + 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
B1H21_RS04160 845759..846169 + 411 WP_021242050.1 protein YgfX Toxin
B1H21_RS04165 846176..846697 - 522 WP_008499710.1 flavodoxin FldB -
B1H21_RS04170 846799..847695 + 897 WP_063418237.1 site-specific tyrosine recombinase XerD -
B1H21_RS04175 847724..848437 + 714 WP_063418238.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
B1H21_RS04180 848443..850176 + 1734 WP_063418239.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T73320 WP_021242050.1 NZ_CP019839:845759-846169 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T73320 NZ_CP019839:845759-846169 [Enterobacter roggenkampii]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGCTACTTTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAAATCAAGTTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCTGACAGTATGGATGCTGCCGAATGGCGAGACCTGCGCCGGATGCTGTTGCAACAGACGA
CGCAGGGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT73320 WP_006178375.1 NZ_CP019839:845512-845778 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT73320 NZ_CP019839:845512-845778 [Enterobacter roggenkampii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACACCTTAAGCGACGACGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References