Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3070335..3070982 Replicon chromosome
Accession NZ_CP019799
Organism Cellvibrio sp. PSBB023

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag B0D95_RS13385 Protein ID WP_078044358.1
Coordinates 3070335..3070739 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID -
Locus tag B0D95_RS13390 Protein ID WP_078044359.1
Coordinates 3070752..3070982 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0D95_RS13360 3065618..3067228 - 1611 WP_141229426.1 methyl-accepting chemotaxis protein -
B0D95_RS13370 3067744..3069222 + 1479 WP_078044355.1 tRNA 4-thiouridine(8) synthase ThiI -
B0D95_RS13380 3069582..3070313 + 732 WP_078044357.1 heme ABC transporter permease CcmC -
B0D95_RS13385 3070335..3070739 - 405 WP_078044358.1 type II toxin-antitoxin system VapC family toxin Toxin
B0D95_RS13390 3070752..3070982 - 231 WP_078044359.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
B0D95_RS13395 3071167..3072993 + 1827 WP_078044360.1 translational GTPase TypA -
B0D95_RS13400 3073141..3073944 + 804 WP_078044361.1 sulfite exporter TauE/SafE family protein -
B0D95_RS13405 3073992..3075014 - 1023 WP_078044362.1 ferrochelatase -
B0D95_RS13410 3075198..3075572 + 375 WP_078044363.1 DUF393 domain-containing protein -
B0D95_RS13415 3075605..3075886 + 282 WP_078044364.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-127)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15118.15 Da        Isoelectric Point: 5.6058

>T73316 WP_078044358.1 NZ_CP019799:c3070739-3070335 [Cellvibrio sp. PSBB023]
MTIRYLLDTNICIYIAKYNPASVRARFAQHSANELAMSVITLGELRFGAEKSHTKDQAMAVIDELASLMNVEELGDGVTE
HYGDIRARLQKSGQIIGNNDLWLAAHARSQDWVLVTNNEKEFVRVDGLRVENWV

Download         Length: 405 bp

>T73316 NZ_CP019799:c3070739-3070335 [Cellvibrio sp. PSBB023]
ATGACAATACGCTATCTGCTCGATACGAATATCTGTATTTATATCGCTAAATATAATCCCGCCTCTGTACGTGCACGCTT
CGCACAGCATTCTGCAAATGAATTGGCGATGTCAGTTATCACTTTGGGCGAGTTGCGCTTCGGTGCTGAGAAAAGTCATA
CAAAAGATCAGGCTATGGCTGTTATTGATGAACTAGCCAGCCTGATGAATGTTGAAGAGCTTGGTGACGGCGTGACCGAG
CACTATGGAGACATCCGTGCACGGCTACAAAAGTCTGGCCAGATCATCGGCAATAATGACTTGTGGCTTGCAGCCCATGC
CCGCTCTCAAGATTGGGTGCTGGTAACCAATAATGAAAAAGAATTTGTGCGAGTAGATGGACTGCGCGTGGAGAATTGGG
TCTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8753.87 Da        Isoelectric Point: 4.5105

>AT73316 WP_078044359.1 NZ_CP019799:c3070982-3070752 [Cellvibrio sp. PSBB023]
MTLARVFQSGNSQAVRLPKEFRFDVDQVEIFRRGDEIILRAVNPNAGVIFDTLTRLPTDFMAQGRDDLPPQERDDF

Download         Length: 231 bp

>AT73316 NZ_CP019799:c3070982-3070752 [Cellvibrio sp. PSBB023]
ATGACACTTGCTCGTGTTTTTCAATCCGGTAATAGCCAGGCAGTAAGGCTCCCCAAAGAGTTTCGTTTTGATGTTGACCA
GGTTGAAATTTTCCGGCGTGGCGATGAAATTATCTTGCGTGCGGTGAACCCCAATGCCGGCGTTATCTTTGACACACTTA
CCCGACTCCCAACCGATTTTATGGCACAAGGTCGGGATGATTTGCCTCCTCAGGAAAGGGACGATTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References