Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 5167054..5167579 Replicon chromosome
Accession NZ_CP019798
Organism Streptomyces sp. fd1-xmd

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag B1K54_RS23500 Protein ID WP_078095014.1
Coordinates 5167054..5167317 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag B1K54_RS23505 Protein ID WP_072483971.1
Coordinates 5167310..5167579 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B1K54_RS23480 5163335..5164339 + 1005 WP_030850346.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
B1K54_RS23485 5164361..5165098 + 738 WP_030850343.1 ROK family protein -
B1K54_RS23490 5165230..5165745 - 516 WP_063898600.1 hypothetical protein -
B1K54_RS23495 5165881..5166969 + 1089 WP_060180501.1 redox-regulated ATPase YchF -
B1K54_RS23500 5167054..5167317 - 264 WP_078095014.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B1K54_RS23505 5167310..5167579 - 270 WP_072483971.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
B1K54_RS23510 5167802..5168383 - 582 WP_078095015.1 Uma2 family endonuclease -
B1K54_RS23515 5168511..5169119 + 609 WP_030850273.1 DUF308 domain-containing protein -
B1K54_RS23520 5169174..5169554 + 381 WP_076043371.1 PadR family transcriptional regulator -
B1K54_RS23525 5169551..5170108 + 558 WP_060180508.1 hypothetical protein -
B1K54_RS23530 5170122..5171183 - 1062 WP_078095016.1 SMP-30/gluconolactonase/LRE family protein -
B1K54_RS23535 5171353..5171790 + 438 WP_173675255.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5160475..5173895 13420


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-59)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10074.52 Da        Isoelectric Point: 8.5041

>T73315 WP_078095014.1 NZ_CP019798:c5167317-5167054 [Streptomyces sp. fd1-xmd]
VSDYRTVFRPEAQAELRKIPRDMALRIMAKLTELESDPFGLNTTALVSQPERRRLRVGDYRVVYTIDNGELVVWVVHVGH
RSTVYDT

Download         Length: 264 bp

>T73315 NZ_CP019798:c5167317-5167054 [Streptomyces sp. fd1-xmd]
GTGAGTGACTATCGCACGGTGTTCCGGCCAGAGGCCCAGGCCGAGCTGCGCAAGATCCCGCGTGACATGGCGCTTCGCAT
CATGGCCAAACTGACAGAGCTGGAGAGCGACCCTTTCGGCTTGAACACCACCGCACTCGTATCCCAGCCTGAGCGCCGCC
GCCTACGAGTCGGCGACTATCGCGTCGTCTACACCATCGACAACGGGGAACTAGTGGTGTGGGTCGTACACGTCGGACAC
CGTTCCACGGTCTACGACACGTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10239.70 Da        Isoelectric Point: 4.7473

>AT73315 WP_072483971.1 NZ_CP019798:c5167579-5167310 [Streptomyces sp. fd1-xmd]
MTQPLPIESIRDVRAHLAEVVERADRDDMPTVITRRGKQVAAVVSIEVLRKYQEWEEREINRIIDERMASPAAGVPIEDV
MRETLARSE

Download         Length: 270 bp

>AT73315 NZ_CP019798:c5167579-5167310 [Streptomyces sp. fd1-xmd]
ATGACTCAGCCGCTGCCCATAGAGTCCATCCGCGACGTACGCGCTCACCTGGCCGAAGTCGTCGAACGGGCCGACCGCGA
CGACATGCCCACCGTCATCACCCGCCGCGGCAAGCAGGTCGCCGCCGTGGTCTCGATAGAGGTGCTGCGCAAGTATCAGG
AGTGGGAAGAGCGCGAGATCAACCGCATCATTGACGAGCGCATGGCGAGCCCGGCCGCCGGCGTCCCGATCGAGGACGTG
ATGAGGGAGACGCTGGCACGCAGTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References