Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 23183..23775 | Replicon | plasmid pVbh_BscR1 |
| Accession | NZ_CP019790 | ||
| Organism | Bartonella schoenbuchensis R1 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | N6UCZ1 |
| Locus tag | BscR1v2_RS07705 | Protein ID | WP_010703152.1 |
| Coordinates | 23183..23383 (+) | Length | 67 a.a. |
Antitoxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | BscR1v2_RS07710 | Protein ID | WP_078690364.1 |
| Coordinates | 23380..23775 (+) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BscR1v2_RS07645 (BscR1v2_016390) | 18262..18534 | - | 273 | WP_010703143.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| BscR1v2_RS07650 (BscR1v2_016400) | 18782..19291 | - | 510 | WP_078690359.1 | hypothetical protein | - |
| BscR1v2_RS07660 (BscR1v2_016410) | 20173..20493 | + | 321 | WP_034989847.1 | helix-turn-helix domain-containing protein | - |
| BscR1v2_RS08145 (BscR1v2_016420) | 20609..21133 | - | 525 | WP_010703147.1 | hypothetical protein | - |
| BscR1v2_RS07670 (BscR1v2_016430) | 21159..21464 | - | 306 | WP_010703148.1 | hypothetical protein | - |
| BscR1v2_RS07675 | 21657..21878 | - | 222 | Protein_31 | hypothetical protein | - |
| BscR1v2_RS07680 | 21875..22183 | - | 309 | WP_034989869.1 | HigA family addiction module antidote protein | - |
| BscR1v2_RS07690 | 22262..22420 | - | 159 | Protein_33 | type II toxin-antitoxin system HicB family antitoxin | - |
| BscR1v2_RS07695 (BscR1v2_016460) | 22417..22701 | - | 285 | WP_010703150.1 | putative addiction module antidote protein | - |
| BscR1v2_RS07700 (BscR1v2_016470) | 22682..22990 | - | 309 | WP_034989871.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| BscR1v2_RS07705 (BscR1v2_016480) | 23183..23383 | + | 201 | WP_010703152.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| BscR1v2_RS07710 (BscR1v2_016490) | 23380..23775 | + | 396 | WP_078690364.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| BscR1v2_RS07720 (BscR1v2_016500) | 24169..24441 | - | 273 | WP_078690365.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| BscR1v2_RS08150 (BscR1v2_016510) | 24521..24691 | - | 171 | WP_194284961.1 | hypothetical protein | - |
| BscR1v2_RS08100 (BscR1v2_016520) | 24898..25053 | - | 156 | WP_010703154.1 | hypothetical protein | - |
| BscR1v2_RS08105 (BscR1v2_016530) | 25053..25271 | + | 219 | WP_141638309.1 | hypothetical protein | - |
| BscR1v2_RS07725 (BscR1v2_016540) | 25316..25744 | - | 429 | WP_010703155.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| BscR1v2_RS07730 (BscR1v2_016550) | 25808..25999 | - | 192 | WP_010703156.1 | hypothetical protein | - |
| BscR1v2_RS07735 (BscR1v2_016560) | 26141..26434 | - | 294 | WP_010703157.1 | HigA family addiction module antidote protein | - |
| BscR1v2_RS07740 (BscR1v2_016570) | 26451..26732 | - | 282 | WP_078690366.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| BscR1v2_RS07745 (BscR1v2_016580) | 27005..27316 | - | 312 | WP_010703159.1 | transcriptional regulator | - |
| BscR1v2_RS07750 | 27329..27652 | - | 324 | Protein_47 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| BscR1v2_RS07755 | 27960..28348 | + | 389 | Protein_48 | single-stranded DNA-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | virB4 / virB11 | 1..55761 | 55761 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 67 a.a. Molecular weight: 7419.77 Da Isoelectric Point: 10.7294
>T73309 WP_010703152.1 NZ_CP019790:23183-23383 [Bartonella schoenbuchensis R1]
MEQDSRKIIAKLKCDGFELVKVKGSHHKFKKNGQVIIVPHPKKDLPIGTARSIAQQAGWLKKGKEE
MEQDSRKIIAKLKCDGFELVKVKGSHHKFKKNGQVIIVPHPKKDLPIGTARSIAQQAGWLKKGKEE
Download Length: 201 bp
>T73309 NZ_CP019790:23183-23383 [Bartonella schoenbuchensis R1]
ATGGAACAAGATAGCCGAAAAATCATTGCAAAATTGAAGTGTGACGGCTTTGAACTTGTTAAAGTAAAAGGTTCTCATCA
TAAATTTAAGAAAAATGGTCAAGTAATTATTGTTCCCCATCCTAAAAAAGATCTTCCAATCGGTACAGCACGTTCCATTG
CACAACAAGCGGGCTGGTTAAAAAAAGGAAAAGAAGAATGA
ATGGAACAAGATAGCCGAAAAATCATTGCAAAATTGAAGTGTGACGGCTTTGAACTTGTTAAAGTAAAAGGTTCTCATCA
TAAATTTAAGAAAAATGGTCAAGTAATTATTGTTCCCCATCCTAAAAAAGATCTTCCAATCGGTACAGCACGTTCCATTG
CACAACAAGCGGGCTGGTTAAAAAAAGGAAAAGAAGAATGA
Antitoxin
Download Length: 132 a.a. Molecular weight: 14820.01 Da Isoelectric Point: 4.5812
>AT73309 WP_078690364.1 NZ_CP019790:23380-23775 [Bartonella schoenbuchensis R1]
MKRFFALVHKDENSAFGVQFPDFKGLFSAADQEEKLIANATEALQLYCEEMDKLPTPLKFEEVIQKETVKIALSEGAFLI
QVPFIENDSEVVRMNISIERGLLRAIDDCAQERGLTRSAFLATAVRHELNI
MKRFFALVHKDENSAFGVQFPDFKGLFSAADQEEKLIANATEALQLYCEEMDKLPTPLKFEEVIQKETVKIALSEGAFLI
QVPFIENDSEVVRMNISIERGLLRAIDDCAQERGLTRSAFLATAVRHELNI
Download Length: 396 bp
>AT73309 NZ_CP019790:23380-23775 [Bartonella schoenbuchensis R1]
ATGAAAAGATTTTTTGCTCTTGTTCACAAGGATGAAAATTCTGCTTTTGGTGTTCAGTTTCCTGATTTTAAAGGACTATT
TTCTGCTGCCGATCAGGAAGAAAAACTTATTGCTAATGCAACAGAAGCTCTTCAACTATATTGCGAAGAAATGGATAAAT
TGCCAACTCCTTTAAAATTTGAAGAAGTCATACAGAAAGAAACTGTCAAAATAGCTTTGTCGGAAGGAGCTTTTTTAATA
CAAGTTCCATTTATTGAAAATGATTCAGAAGTGGTGCGTATGAATATATCAATTGAACGAGGGCTCTTGCGTGCAATTGA
TGATTGTGCACAAGAAAGAGGGTTAACACGATCTGCTTTTTTAGCAACAGCAGTACGTCACGAGCTTAATATTTAG
ATGAAAAGATTTTTTGCTCTTGTTCACAAGGATGAAAATTCTGCTTTTGGTGTTCAGTTTCCTGATTTTAAAGGACTATT
TTCTGCTGCCGATCAGGAAGAAAAACTTATTGCTAATGCAACAGAAGCTCTTCAACTATATTGCGAAGAAATGGATAAAT
TGCCAACTCCTTTAAAATTTGAAGAAGTCATACAGAAAGAAACTGTCAAAATAGCTTTGTCGGAAGGAGCTTTTTTAATA
CAAGTTCCATTTATTGAAAATGATTCAGAAGTGGTGCGTATGAATATATCAATTGAACGAGGGCTCTTGCGTGCAATTGA
TGATTGTGCACAAGAAAGAGGGTTAACACGATCTGCTTTTTTAGCAACAGCAGTACGTCACGAGCTTAATATTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|