Detailed information of TA system TA073304

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 390694..391241
• Replicon: chromosome
• Accession: NZ_CP019786
• Organism: Bartonella sp. Raccoon60

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: Bra60_RS01550
• Protein ID: WP_078689029.1
• Coordinates: 390918..391241 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: Bra60_RS01545
• Protein ID: WP_078688397.1
• Coordinates: 390694..390918 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Bra60_RS01530	387581..388494	+	914	Protein_320	YopJ family type III secretion system effector serine/threonine acetyltransferase	-
Bra60_RS01540	389871..390551	-	681	WP_078698017.1	lysozyme	-
Bra60_RS01545	390694..390918	+	225	WP_078688397.1	antitoxin MazE family protein	Antitoxin
Bra60_RS01550	390918..391241	+	324	WP_078689029.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
Bra60_RS01560	391603..392025	-	423	WP_078688398.1	type II toxin-antitoxin system VapC family toxin	-
Bra60_RS01565	392026..392289	-	264	WP_078688399.1	type II toxin-antitoxin system VapB family antitoxin	-
Bra60_RS01570	392419..393726	-	1308	WP_078688400.1	late control protein	-
Bra60_RS01575	393723..393947	-	225	WP_078688401.1	tail protein X	-
Bra60_RS01580	393944..394324	-	381	WP_078688402.1	phage tail protein	-
Bra60_RS01585	394330..396212	-	1883	Protein_329	phage tail protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	389871..442184	52313

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-102)

Antitoxin

• Antitoxin MazE-like (7-72)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 11857.15 Da
• Isoelectric Point: 9.9803

>T73304 WP_078689029.1 NZ_CP019786:390918-391241 [Bartonella sp. Raccoon60]
MRGSLITIAIQGDFGKPRPALIIQANQFSEHTSMTVLPITSTLVDAPLLRITIQPNTKNGLQKPSQVMIDKIMTVRCDKM
SSIFGSLKEKEMLEIERCLAVFLGIVK

Nucleotide

• Length: 324 bp

>T73304 NZ_CP019786:390918-391241 [Bartonella sp. Raccoon60]
ATGCGTGGTTCTCTGATAACAATAGCGATACAAGGTGATTTTGGTAAACCAAGACCCGCATTGATCATTCAAGCTAATCA
ATTTAGTGAACATACCAGCATGACGGTTTTACCAATTACAAGCACACTTGTTGATGCGCCATTACTCCGCATTACGATTC
AACCAAACACCAAAAATGGCTTACAAAAACCTTCGCAAGTAATGATTGATAAGATTATGACTGTAAGGTGTGATAAAATG
AGTTCCATTTTTGGTTCTCTTAAAGAAAAGGAAATGCTAGAGATTGAACGGTGTTTGGCTGTATTTTTAGGAATAGTAAA
ATAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8742.09 Da
• Isoelectric Point: 8.5634

>AT73304 WP_078688397.1 NZ_CP019786:390694-390918 [Bartonella sp. Raccoon60]
MGTMHVNERVQKHRNAQRKAGLRLMQIWVPDTRQPNFAEECRRQCRLVAKIDKVDTAIQLFMDQSLMDVDGWTE

Nucleotide

• Length: 225 bp

>AT73304 NZ_CP019786:390694-390918 [Bartonella sp. Raccoon60]
ATGGGTACAATGCATGTTAATGAACGTGTTCAAAAACATCGCAACGCACAAAGAAAAGCGGGATTGCGCTTAATGCAAAT
TTGGGTACCAGATACACGCCAGCCAAATTTTGCAGAAGAGTGTCGCCGTCAATGTCGCTTAGTAGCAAAAATCGATAAAG
TTGATACAGCTATACAGTTGTTTATGGATCAATCTTTAATGGATGTTGATGGTTGGACAGAATGA