Detailed information of TA system TA073303

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 1361595..1362142
• Replicon: chromosome
• Accession: NZ_CP019781
• Organism: Bartonella sp. WD16.2

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: BWD162_RS05970
• Protein ID: WP_078705832.1
• Coordinates: 1361595..1361918 (-)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: BWD162_RS05975
• Protein ID: WP_078705833.1
• Coordinates: 1361921..1362142 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BWD162_RS05940	1356783..1356971	-	189	WP_078705829.1	hypothetical protein	-
BWD162_RS05945	1356987..1357943	-	957	WP_078705830.1	hypothetical protein	-
BWD162_RS05950	1358425..1359294	-	870	WP_078705831.1	hypothetical protein	-
BWD162_RS05955	1359742..1360134	-	393	WP_078706157.1	helix-turn-helix domain-containing protein	-
BWD162_RS05960	1361011..1361302	-	292	Protein_1132	HigA family addiction module antidote protein	-
BWD162_RS05970	1361595..1361918	-	324	WP_078705832.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
BWD162_RS05975	1361921..1362142	-	222	WP_078705833.1	antitoxin MazE family protein	Antitoxin
BWD162_RS07805	1362340..1362492	+	153	WP_194284856.1	hypothetical protein	-
BWD162_RS05990	1363460..1365021	+	1562	Protein_1136	murein biosynthesis integral membrane protein MurJ	-
BWD162_RS05995	1365102..1366169	+	1068	WP_078706158.1	tryptophan--tRNA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-102)

Antitoxin

• Antitoxin MazE-like (7-72)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 11760.93 Da
• Isoelectric Point: 8.5407

>T73303 WP_078705832.1 NZ_CP019781:c1361918-1361595 [Bartonella sp. WD16.2]
MRGSLITVAIRGDFGKPRPALVIQANQFSEHTSITVLPITSTLIAAPLLRVTIEPNSENGLLKPSQVMIDKIVTVRCDKI
SSIFGYIHTDEMIQIERCLAVFLGIVK

Nucleotide

• Length: 324 bp

>T73303 NZ_CP019781:c1361918-1361595 [Bartonella sp. WD16.2]
ATGAGAGGTTCTCTTATAACAGTAGCTATACGAGGCGATTTTGGTAAACCAAGACCCGCATTGGTAATCCAGGCTAATCA
ATTTAGTGAGCATACAAGTATCACAGTTTTACCAATTACAAGCACACTTATTGCTGCTCCACTGCTGCGCGTTACCATTG
AGCCAAATAGTGAAAATGGTCTGCTAAAACCTTCACAGGTGATGATTGATAAAATTGTGACGGTACGATGTGATAAAATT
AGTTCAATTTTCGGTTATATTCACACAGATGAAATGATACAAATTGAACGCTGTTTAGCTGTATTTTTAGGAATAGTAAA
ATGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8539.81 Da
• Isoelectric Point: 8.2819

>AT73303 WP_078705833.1 NZ_CP019781:c1362142-1361921 [Bartonella sp. WD16.2]
MGTMHVNERVQKYRNAQRKAGLRLIQIWVPDIRKPNFAEECCRQCRLVAETDKTNASVQLFMEQSLTDIDGWT

Nucleotide

• Length: 222 bp

>AT73303 NZ_CP019781:c1362142-1361921 [Bartonella sp. WD16.2]
ATGGGCACAATGCATGTCAATGAACGCGTTCAAAAATATCGCAATGCACAGAGAAAAGCTGGATTGCGTTTAATACAAAT
TTGGGTACCAGATATACGTAAACCGAACTTTGCTGAAGAATGCTGTCGTCAATGTCGTTTAGTAGCAGAGACAGATAAAA
CTAATGCATCTGTTCAATTATTTATGGAGCAATCTTTAACGGATATTGATGGCTGGACATAA