Detailed information of TA system TA073300

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 1197977..1198457
• Replicon: chromosome
• Accession: NZ_CP019781
• Organism: Bartonella sp. WD16.2

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: BWD162_RS05090
• Protein ID: WP_078663354.1
• Coordinates: 1198188..1198457 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: N6ULI8
• Locus tag: BWD162_RS05085
• Protein ID: WP_010703919.1
• Coordinates: 1197977..1198204 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BWD162_RS05045	1193437..1194514	+	1078	Protein_956	tyrosine-type recombinase/integrase	-
BWD162_RS05050	1194790..1195530	+	741	WP_078705699.1	antA/AntB antirepressor family protein	-
BWD162_RS05055	1195494..1195802	+	309	WP_194284851.1	hypothetical protein	-
BWD162_RS05060	1195862..1196161	-	300	WP_078705701.1	putative addiction module antidote protein	-
BWD162_RS05065	1196142..1196450	-	309	WP_078705702.1	type II toxin-antitoxin system RelE/ParE family toxin	-
BWD162_RS05075	1196872..1197302	+	431	Protein_961	single-stranded DNA-binding protein	-
BWD162_RS05080	1197335..1197871	+	537	WP_078705704.1	hypothetical protein	-
BWD162_RS05085	1197977..1198204	+	228	WP_010703919.1	ribbon-helix-helix protein, CopG family	Antitoxin
BWD162_RS05090	1198188..1198457	+	270	WP_078663354.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BWD162_RS05095	1198764..1199264	+	501	WP_078705705.1	hypothetical protein	-
BWD162_RS05100	1199268..1200291	+	1024	Protein_966	N-6 DNA methylase	-
BWD162_RS05105	1200305..1200892	+	588	WP_078705706.1	hypothetical protein	-
BWD162_RS05110	1201134..1201430	-	297	WP_010704172.1	HigA family addiction module antidote protein	-
BWD162_RS05115	1201447..1201761	-	315	WP_078705707.1	type II toxin-antitoxin system RelE/ParE family toxin	-
BWD162_RS05120	1201822..1202113	+	292	Protein_970	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (2-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10504.53 Da
• Isoelectric Point: 10.3849

>T73300 WP_078663354.1 NZ_CP019781:1198188-1198457 [Bartonella sp. WD16.2]
MAWTIRYEKKALNFLKKCDKKEARRIVDFLDKHIALLEDVRVVGKPLKGPLSGLWRYRVGDYRILCDLHDKELLVLVLAV
GHRKNIYKN

Nucleotide

• Length: 270 bp

>T73300 NZ_CP019781:1198188-1198457 [Bartonella sp. WD16.2]
TTGGCTTGGACGATTAGATATGAAAAAAAGGCTCTCAATTTTTTAAAAAAATGTGATAAAAAAGAAGCACGACGGATTGT
TGATTTTTTAGATAAGCACATTGCTCTGCTTGAAGATGTGCGTGTAGTGGGTAAGCCTTTGAAAGGTCCATTATCAGGTT
TGTGGAGATATCGTGTGGGAGATTACAGGATATTATGTGATCTCCACGATAAAGAGCTTTTGGTCTTGGTTTTGGCTGTG
GGACATAGAAAAAATATATATAAAAACTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8728.79 Da
• Isoelectric Point: 4.6561

>AT73300 WP_010703919.1 NZ_CP019781:1197977-1198204 [Bartonella sp. WD16.2]
MTISIRLPSDLETRLNNLALKTGRTKSFYLREIIEQGIEEAEDYYLASQVRERVRKGDATFYSSEEVRKELGLDD

Nucleotide

• Length: 228 bp

>AT73300 NZ_CP019781:1197977-1198204 [Bartonella sp. WD16.2]
ATGACAATATCTATTCGATTGCCAAGTGATCTTGAAACGCGTTTGAATAATTTAGCCCTTAAAACAGGACGTACAAAGTC
TTTTTATTTGCGTGAGATTATTGAACAGGGAATAGAGGAAGCTGAGGATTATTATTTAGCTTCACAAGTAAGAGAACGTG
TTCGAAAGGGAGATGCTACTTTTTATAGCTCTGAAGAGGTGAGGAAAGAGCTTGGCTTGGACGATTAG

Structures

Antitoxin

• AlphaFold DB: N6ULI8