Detailed information of TA system TA073299

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 893871..894463
• Replicon: chromosome
• Accession: NZ_CP019781
• Organism: Bartonella sp. WD16.2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: N6UCZ1
• Locus tag: BWD162_RS03785
• Protein ID: WP_010703152.1
• Coordinates: 893871..894071 (+)
• Length: 67 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: BWD162_RS03790
• Protein ID: WP_078705506.1
• Coordinates: 894068..894463 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BWD162_RS03745	889107..889847	+	741	WP_078705499.1	antA/AntB antirepressor family protein	-
BWD162_RS03750	889811..890122	+	312	Protein_715	hypothetical protein	-
BWD162_RS03755	890167..890595	-	429	WP_078705500.1	type II toxin-antitoxin system HicB family antitoxin	-
BWD162_RS03760	890967..891260	-	294	WP_078705501.1	HigA family addiction module antidote protein	-
BWD162_RS03765	891277..891558	-	282	WP_078705502.1	type II toxin-antitoxin system RelE/ParE family toxin	-
BWD162_RS07825	891627..892121	-	495	WP_210186499.1	DUF488 family protein	-
BWD162_RS03775	892808..893257	+	450	WP_078705504.1	single-stranded DNA-binding protein	-
BWD162_RS03780	893272..893802	+	531	WP_078705505.1	hypothetical protein	-
BWD162_RS03785	893871..894071	+	201	WP_010703152.1	type II toxin-antitoxin system HicA family toxin	Toxin
BWD162_RS03790	894068..894463	+	396	WP_078705506.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BWD162_RS03795	894823..895263	+	441	WP_078705507.1	hypothetical protein	-
BWD162_RS03800	895267..898024	+	2758	Protein_725	DEAD/DEAH box helicase	-
BWD162_RS03805	898628..899101	-	474	WP_078706133.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	873257..899266	26009

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-125)

Sequences

Toxin

Protein

• Length: 67 a.a.
• Molecular weight: 7419.77 Da
• Isoelectric Point: 10.7294

>T73299 WP_010703152.1 NZ_CP019781:893871-894071 [Bartonella sp. WD16.2]
MEQDSRKIIAKLKCDGFELVKVKGSHHKFKKNGQVIIVPHPKKDLPIGTARSIAQQAGWLKKGKEE

Nucleotide

• Length: 201 bp

>T73299 NZ_CP019781:893871-894071 [Bartonella sp. WD16.2]
ATGGAACAAGATAGCCGAAAAATCATTGCAAAATTAAAGTGTGACGGCTTTGAACTTGTTAAAGTAAAAGGTTCTCATCA
TAAATTTAAAAAAAATGGTCAAGTAATTATCGTTCCCCATCCTAAAAAAGACTTGCCAATTGGTACAGCGCGTTCCATTG
CACAACAAGCGGGCTGGTTAAAAAAAGGAAAAGAAGAATGA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14791.91 Da
• Isoelectric Point: 4.4767

>AT73299 WP_078705506.1 NZ_CP019781:894068-894463 [Bartonella sp. WD16.2]
MKRFFALVHKDENSAFGVQFPDFKGLFSAADQEENLIANATEALQLYCEEMDKLPTPLKFEEVIQKETIKIALSEGAFLI
QVPFIENDSEVVRMNISIERGLLRAIDDCAQERGLTRSAFLATAARHELNI

Nucleotide

• Length: 396 bp

>AT73299 NZ_CP019781:894068-894463 [Bartonella sp. WD16.2]
ATGAAAAGATTTTTTGCTCTTGTTCACAAGGATGAAAATTCTGCTTTTGGTGTTCAGTTTCCTGATTTTAAAGGACTATT
TTCTGCTGCCGATCAGGAAGAAAATCTTATTGCTAATGCAACAGAAGCTCTTCAATTATATTGCGAAGAAATGGATAAAT
TGCCAACTCCTTTAAAATTTGAAGAAGTGATACAGAAAGAAACTATCAAAATAGCTTTGTCGGAAGGAGCTTTTTTAATA
CAAGTTCCATTTATTGAAAATGATTCAGAAGTGGTGCGTATGAATATATCAATTGAACGAGGGCTCTTGCGTGCAATTGA
TGATTGTGCACAAGAAAGAGGCTTAACACGATCTGCCTTTTTAGCAACGGCAGCACGTCATGAGCTTAATATTTGA

Structures

Toxin

• AlphaFold DB: N6UCZ1