Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 752094..752683 Replicon chromosome
Accession NZ_CP019781
Organism Bartonella sp. WD16.2

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag BWD162_RS03125 Protein ID WP_078705396.1
Coordinates 752351..752683 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag BWD162_RS03120 Protein ID WP_078705395.1
Coordinates 752094..752351 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWD162_RS03080 747167..748054 + 888 WP_078705388.1 hypothetical protein -
BWD162_RS03085 748014..748433 + 420 WP_194284866.1 hypothetical protein -
BWD162_RS03090 748934..749587 + 654 WP_078705389.1 hypothetical protein -
BWD162_RS03095 749761..750072 - 312 WP_078705390.1 addiction module antidote protein -
BWD162_RS03100 750085..750408 - 324 WP_078705391.1 type II toxin-antitoxin system RelE/ParE family toxin -
BWD162_RS03105 750744..751178 + 435 WP_078705392.1 single-stranded DNA-binding protein -
BWD162_RS03115 751495..752040 + 546 WP_078705394.1 hypothetical protein -
BWD162_RS03120 752094..752351 + 258 WP_078705395.1 antitoxin Antitoxin
BWD162_RS03125 752351..752683 + 333 WP_078705396.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BWD162_RS03130 752684..752977 - 294 WP_078705397.1 hypothetical protein -
BWD162_RS03135 753352..753672 + 321 WP_078705398.1 hypothetical protein -
BWD162_RS03140 753684..755009 + 1326 WP_078705399.1 phage terminase large subunit -
BWD162_RS03145 754994..757036 + 2043 WP_078705400.1 phage portal protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 703654..772462 68808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11852.99 Da        Isoelectric Point: 10.5590

>T73298 WP_078705396.1 NZ_CP019781:752351-752683 [Bartonella sp. WD16.2]
MNRGEIWLVSLDPSSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGSFARIAGFVVSLMGVGLHTTGVIRCDQPRAL
DIGARKGKKLETVPVMIMNEVLAKLSTFLT

Download         Length: 333 bp

>T73298 NZ_CP019781:752351-752683 [Bartonella sp. WD16.2]
ATGAATCGGGGAGAAATTTGGTTAGTATCGCTTGACCCAAGTTCAGGATATGAGCAAAAAGGAACGCGTCCGGTGCTTAT
TGTATCACCAGAGGCGTTTAATCGTGTGACTAAAACACCAATTGTCTTACCCATTACAAGTGGAGGAAGTTTTGCTAGAA
TAGCGGGTTTTGTTGTTTCGTTGATGGGAGTTGGATTGCATACAACAGGTGTGATACGCTGTGATCAACCACGTGCTCTC
GATATAGGAGCGCGCAAAGGAAAAAAACTAGAAACGGTTCCTGTCATGATTATGAACGAAGTATTAGCTAAGTTATCAAC
ATTCCTTACGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9403.84 Da        Isoelectric Point: 3.9817

>AT73298 WP_078705395.1 NZ_CP019781:752094-752351 [Bartonella sp. WD16.2]
MHTTKLRKVGGSVMLSIPPALLDVLHLVENTEVGLTIDNGCLIVEPQVFPSYTLDELLAQCDPLADLYDEETKWLDAEPV
GRELL

Download         Length: 258 bp

>AT73298 NZ_CP019781:752094-752351 [Bartonella sp. WD16.2]
ATGCACACAACGAAATTGCGTAAAGTTGGAGGGTCAGTTATGCTCTCTATACCGCCTGCGTTACTTGATGTTTTACACCT
CGTTGAAAATACTGAGGTTGGTTTGACTATTGATAATGGGTGTTTAATTGTAGAGCCTCAGGTATTTCCTAGTTATACTC
TTGACGAATTGTTAGCTCAATGTGATCCTTTGGCTGACCTCTATGATGAGGAAACGAAATGGCTTGATGCTGAACCTGTT
GGTAGAGAGCTCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References