Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3425305..3426100 | Replicon | chromosome |
| Accession | NZ_CP019778 | ||
| Organism | Escherichia coli strain NCTC86 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A4Y9BN12 |
| Locus tag | B0915_RS17580 | Protein ID | WP_023909482.1 |
| Coordinates | 3425726..3426100 (+) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | B0915_RS17575 | Protein ID | WP_001522275.1 |
| Coordinates | 3425305..3425679 (+) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| B0915_RS17545 | 3420467..3421285 | + | 819 | WP_001522287.1 | DUF945 domain-containing protein | - |
| B0915_RS26955 | 3421285..3421461 | + | 177 | WP_001522285.1 | hypothetical protein | - |
| B0915_RS17550 | 3421556..3422029 | + | 474 | WP_001522284.1 | antirestriction protein | - |
| B0915_RS17555 | 3422044..3422520 | + | 477 | WP_001186724.1 | RadC family protein | - |
| B0915_RS17560 | 3422701..3424200 | + | 1500 | WP_001522281.1 | IS21-like element ISEc10 family transposase | - |
| B0915_RS17565 | 3424197..3424952 | + | 756 | WP_001522280.1 | IS21-like element ISEc10 family helper ATPase IstB | - |
| B0915_RS17570 | 3425004..3425225 | + | 222 | WP_023909484.1 | DUF987 domain-containing protein | - |
| B0915_RS17575 | 3425305..3425679 | + | 375 | WP_001522275.1 | type IV toxin-antitoxin system toxin CbtA | Antitoxin |
| B0915_RS17580 | 3425726..3426100 | + | 375 | WP_023909482.1 | TA system toxin CbtA family protein | Toxin |
| B0915_RS17585 | 3426097..3426587 | + | 491 | Protein_3217 | hypothetical protein | - |
| B0915_RS17590 | 3426599..3426796 | + | 198 | WP_001522268.1 | DUF957 domain-containing protein | - |
| B0915_RS17595 | 3426881..3427747 | + | 867 | WP_023909479.1 | DUF4942 domain-containing protein | - |
| B0915_RS17600 | 3427819..3428082 | + | 264 | WP_001143297.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| B0915_RS17605 | 3428079..3428405 | + | 327 | WP_001522265.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| B0915_RS26960 | 3428897..3429052 | + | 156 | WP_000729639.1 | hypothetical protein | - |
| B0915_RS17615 | 3429863..3430846 | + | 984 | WP_066008910.1 | KpsF/GutQ family sugar-phosphate isomerase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | kpsF / kpsE / kpsD / kpsU / kpsC / kpsS / kpsT / kpsM / gspM / gspL / gspK | 3395035..3499392 | 104357 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14009.98 Da Isoelectric Point: 8.2905
>T73288 WP_023909482.1 NZ_CP019778:3425726-3426100 [Escherichia coli]
MKTLSDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRTVNNITQGKHPEAK
MKTLSDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRTVNNITQGKHPEAK
Download Length: 375 bp
>T73288 NZ_CP019778:3425726-3426100 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCGAAATGA
ATGAAAACATTATCCGACACACATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCGAAATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13630.35 Da Isoelectric Point: 5.5051
>AT73288 WP_001522275.1 NZ_CP019778:3425305-3425679 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
Download Length: 375 bp
>AT73288 NZ_CP019778:3425305-3425679 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGATGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCGGTTTATCCGACACCGGCACCCGCAACCACCTCATAA
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGATGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCGGTTTATCCGACACCGGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|