Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 344807..345501 Replicon chromosome
Accession NZ_CP019778
Organism Escherichia coli strain NCTC86

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag B0915_RS01705 Protein ID WP_066009356.1
Coordinates 345133..345501 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag B0915_RS01700 Protein ID WP_077249034.1
Coordinates 344807..345112 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0915_RS01660 340757..341212 + 456 WP_000581506.1 hypothetical protein -
B0915_RS26295 341313..341521 + 209 Protein_305 DUF905 family protein -
B0915_RS01670 341622..342443 + 822 WP_001234565.1 DUF945 domain-containing protein -
B0915_RS01680 342785..343258 + 474 WP_000855059.1 antirestriction protein -
B0915_RS01685 343274..343750 + 477 WP_001424026.1 RadC family protein -
B0915_RS01690 343819..344040 + 222 WP_000692345.1 DUF987 domain-containing protein -
B0915_RS01695 344059..344703 + 645 WP_000086755.1 hypothetical protein -
B0915_RS01700 344807..345112 + 306 WP_077249034.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
B0915_RS01705 345133..345501 + 369 WP_066009356.1 TA system toxin CbtA family protein Toxin
B0915_RS01710 345822..346160 - 339 Protein_313 LysR family transcriptional regulator -
B0915_RS01715 346211..347167 - 957 WP_000121359.1 molybdenum cofactor insertion chaperone PaoD -
B0915_RS01720 347177..349375 - 2199 WP_000667026.1 aldehyde oxidoreductase molybdenum-binding subunit PaoC -
B0915_RS01725 349372..350328 - 957 WP_000643333.1 aldehyde oxidoreductase FAD-binding subunit PaoB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(3-100)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13611.75 Da        Isoelectric Point: 7.7465

>T73269 WP_066009356.1 NZ_CP019778:345133-345501 [Escherichia coli]
MNTLPATISPAAKPCPSPVAVWQMLLTRLLEQHYGLMLSDTPFSDETVIKEHIDASITLANAVNFLVEKYELVRIDRNGF
NSQVQAPYLTATDILQARKACGLMSRCSYRDVSNIVLSRSRL

Download         Length: 369 bp

>T73269 NZ_CP019778:345133-345501 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCTCCGGCGGCGAAGCCCTGTCCGTCGCCCGTTGCAGTCTGGCAAATGTTACTTAC
TCGTTTGCTTGAGCAGCACTATGGCCTAATGCTAAGCGACACACCTTTTAGCGATGAAACCGTTATAAAGGAGCATATTG
ATGCCAGTATCACTCTGGCTAATGCCGTTAACTTTCTGGTAGAGAAATATGAGTTAGTTCGTATTGATCGCAATGGATTT
AACTCTCAGGTACAAGCACCATATTTGACTGCGACAGACATTCTTCAAGCCAGGAAAGCGTGCGGGTTGATGAGCCGGTG
TTCTTACAGAGATGTAAGTAATATTGTTCTTAGCCGATCACGGTTGTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11263.85 Da        Isoelectric Point: 6.0454

>AT73269 WP_077249034.1 NZ_CP019778:344807-345112 [Escherichia coli]
MVGLPYTVTPCSGTRLVQEGNRLYYLADRASITGKFSDAESLKLDVVFPHFISQMESMLTTGEMNPRHAHCFTLYHNGFT
CEADTLGSCGYVYIAIYPTQL

Download         Length: 306 bp

>AT73269 NZ_CP019778:344807-345112 [Escherichia coli]
CTGGTGGGGCTACCCTACACCGTGACGCCCTGTTCTGGCACCCGTCTGGTGCAGGAGGGCAACCGACTGTACTATTTGGC
TGACCGGGCAAGTATCACCGGTAAGTTTAGTGATGCCGAAAGCCTGAAGCTGGATGTCGTATTTCCACATTTTATCAGTC
AGATGGAATCGATGCTGACCACTGGTGAAATGAATCCCCGCCATGCCCACTGTTTCACCCTGTACCACAACGGTTTCACC
TGCGAAGCCGATACCCTTGGTAGTTGCGGCTATGTATACATCGCCATTTATCCCACTCAGCTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References