Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2227844..2228675 Replicon chromosome
Accession NZ_CP019777
Organism Escherichia coli NU14

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag B0908_RS11660 Protein ID WP_000854814.1
Coordinates 2228301..2228675 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag B0908_RS11655 Protein ID WP_001285586.1
Coordinates 2227844..2228212 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0908_RS11615 2222902..2223972 + 1071 WP_000102631.1 patatin-like phospholipase family protein -
B0908_RS11620 2224108..2224785 + 678 WP_001362823.1 hypothetical protein -
B0908_RS11625 2224801..2225211 + 411 WP_000846704.1 hypothetical protein -
B0908_RS11635 2225432..2226253 + 822 WP_001234570.1 DUF945 domain-containing protein -
B0908_RS11640 2226516..2226989 + 474 WP_000855071.1 antirestriction protein -
B0908_RS11645 2227004..2227480 + 477 WP_001298074.1 RadC family protein -
B0908_RS11650 2227549..2227770 + 222 WP_000692323.1 DUF987 domain-containing protein -
B0908_RS11655 2227844..2228212 + 369 WP_001285586.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
B0908_RS11660 2228301..2228675 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
B0908_RS11665 2228672..2228866 + 195 WP_000988601.1 hypothetical protein -
B0908_RS26330 2228879..2228992 + 114 WP_001161660.1 DUF957 domain-containing protein -
B0908_RS11670 2229281..2229427 - 147 Protein_2135 transposase domain-containing protein -
B0908_RS11675 2229481..2229663 + 183 WP_001016348.1 hypothetical protein -
B0908_RS11680 2229764..2230093 - 330 WP_000450409.1 DUF496 family protein -
B0908_RS11685 2230265..2231323 - 1059 WP_001200890.1 FUSC family protein -
B0908_RS11690 2231521..2231994 - 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
B0908_RS11695 2232113..2233278 - 1166 Protein_2140 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T73260 WP_000854814.1 NZ_CP019777:2228301-2228675 [Escherichia coli NU14]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T73260 NZ_CP019777:2228301-2228675 [Escherichia coli NU14]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT73260 WP_001285586.1 NZ_CP019777:2227844-2228212 [Escherichia coli NU14]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT73260 NZ_CP019777:2227844-2228212 [Escherichia coli NU14]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References