Detailed information of TA system TA073219

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 2735008..2735555
• Replicon: chromosome
• Accession: NZ_CP019725
• Organism: Xanthomonas perforans 91-118

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0G9C4Q2
• Locus tag: XPE_RS12370
• Protein ID: WP_008574054.1
• Coordinates: 2735008..2735310 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q3BZM5
• Locus tag: XPE_RS12375
• Protein ID: WP_008574056.1
• Coordinates: 2735298..2735555 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XPE_RS12340	2730337..2730945	+	609	WP_008574046.1	NAD(P)H-dependent oxidoreductase	-
XPE_RS12345	2731183..2731893	-	711	WP_008574047.1	hypothetical protein	-
XPE_RS12350	2732093..2733004	-	912	WP_033478804.1	LysR family transcriptional regulator	-
XPE_RS12355	2733130..2733867	+	738	WP_008574050.1	SDR family oxidoreductase	-
XPE_RS12360	2733927..2734826	+	900	WP_008574052.1	SDR family NAD(P)-dependent oxidoreductase	-
XPE_RS12370	2735008..2735310	-	303	WP_008574054.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
XPE_RS12375	2735298..2735555	-	258	WP_008574056.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
XPE_RS12380	2735621..2736283	-	663	WP_008574057.1	hemolysin III family protein	-
XPE_RS12385	2736461..2738956	+	2496	WP_008574058.1	DEAD/DEAH box helicase	-
XPE_RS12390	2738953..2740410	+	1458	WP_008574059.1	ribonuclease H-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2724185..2735555	11370

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11522.33 Da
• Isoelectric Point: 9.1267

>T73219 WP_008574054.1 NZ_CP019725:c2735310-2735008 [Xanthomonas perforans 91-118]
MAEIIWSVPALADLDAIADDIAIDNAPAAAAALVKWVLPQVERLIEHPDSGSRPQELQRSRYRQIVEPPCRVFYRVDGQR
IVLVHVMRWERALRRNRLSR

Nucleotide

• Length: 303 bp

>T73219 NZ_CP019725:c2735310-2735008 [Xanthomonas perforans 91-118]
ATGGCTGAAATAATCTGGTCGGTGCCGGCATTGGCTGATCTGGACGCAATTGCCGACGACATCGCAATCGATAACGCACC
CGCTGCAGCGGCGGCGCTGGTCAAATGGGTGTTGCCGCAGGTCGAGCGATTGATTGAACACCCGGACAGCGGAAGCCGGC
CACAGGAACTCCAGCGCTCGCGCTATCGCCAGATTGTCGAACCACCTTGCCGCGTGTTCTACCGCGTGGATGGGCAGCGC
ATCGTGCTGGTGCACGTCATGCGGTGGGAGCGCGCGCTTCGCAGGAACCGTCTTTCACGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9686.18 Da
• Isoelectric Point: 10.0780

>AT73219 WP_008574056.1 NZ_CP019725:c2735555-2735298 [Xanthomonas perforans 91-118]
MRTELVTTLKRQATEPLAAAERDKEPILITQHGLPRAYVVDVASDERMQQRIALLEGIARGEMAVAQGRTLRHEQAQQHM
ARWLK

Nucleotide

• Length: 258 bp

>AT73219 NZ_CP019725:c2735555-2735298 [Xanthomonas perforans 91-118]
ATGCGCACCGAACTTGTCACCACGCTCAAGCGTCAGGCGACCGAACCCCTTGCAGCTGCAGAGCGCGACAAGGAGCCAAT
CCTGATCACACAGCACGGTTTACCCAGAGCCTATGTGGTGGATGTTGCCAGCGATGAGCGCATGCAGCAGCGCATTGCGC
TCCTGGAAGGAATCGCCCGTGGAGAAATGGCAGTCGCGCAAGGCCGTACGCTGCGCCATGAACAGGCACAGCAACACATG
GCGCGATGGCTGAAATAA

Structures

Toxin

• AlphaFold DB: A0A0G9C4Q2

Antitoxin

• AlphaFold DB: A0A3G2WGS6