Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 23514..24079 Replicon plasmid unnamed1
Accession NZ_CP019718
Organism Paenibacillus larvae subsp. larvae strain Eric_V

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ERICV_RS24350 Protein ID WP_172423969.1
Coordinates 23514..23843 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag ERICV_RS24355 Protein ID WP_172424007.1
Coordinates 23840..24079 (-) Length 80 a.a.

Genomic Context

ERICV_RS24305ERICV_RS24310ERICV_RS24315ERICV_RS24320ERICV_RS24325ERICV_RS24330ERICV_RS24335ERICV_RS24340ERICV_RS24345ERICV_RS24350ERICV_RS24355ERICV_RS24360ERICV_RS24365ERICV_RS24370ERICV_RS24375ERICV_RS24380ERICV_RS24385ERICV_RS24390ERICV_RS24395ERICV_RS24400ERICV_RS24405ERICV_RS24410ERICV_RS24415
Location: 19434..19676 (243 bp)
Type: Others
Protein ID: WP_172423962.1
Location: 19694..20371 (678 bp)
Type: Others
Protein ID: WP_172423963.1
Location: 20378..20842 (465 bp)
Type: Others
Protein ID: WP_024094413.1
Location: 20860..21135 (276 bp)
Type: Others
Protein ID: WP_036658889.1
Location: 21148..21387 (240 bp)
Type: Others
Protein ID: WP_172423964.1
Location: 21475..21744 (270 bp)
Type: Others
Protein ID: WP_172423965.1
Location: 21784..22026 (243 bp)
Type: Others
Protein ID: WP_172423966.1
Location: 22019..23002 (984 bp)
Type: Others
Protein ID: WP_172423967.1
Location: 23197..23487 (291 bp)
Type: Others
Protein ID: WP_172423968.1
Location: 23514..23843 (330 bp)
Type: Toxin
Protein ID: WP_172423969.1
Location: 23840..24079 (240 bp)
Type: Antitoxin
Protein ID: WP_172424007.1
Location: 24651..25025 (375 bp)
Type: Others
Protein ID: WP_172423970.1
Location: 25009..25197 (189 bp)
Type: Others
Protein ID: WP_172423971.1
Location: 25384..25641 (258 bp)
Type: Others
Protein ID: WP_172423972.1
Location: 25643..26026 (384 bp)
Type: Others
Protein ID: WP_172423973.1
Location: 26033..26323 (291 bp)
Type: Others
Protein ID: WP_172423974.1
Location: 26316..26639 (324 bp)
Type: Others
Protein ID: WP_172423975.1
Location: 26672..26878 (207 bp)
Type: Others
Protein ID: WP_172423976.1
Location: 26887..27585 (699 bp)
Type: Others
Protein ID: WP_172423977.1
Location: 27592..27819 (228 bp)
Type: Others
Protein ID: WP_172423978.1
Location: 28100..28300 (201 bp)
Type: Others
Protein ID: WP_172423979.1
Location: 28303..28503 (201 bp)
Type: Others
Protein ID: WP_172423980.1
Location: 28496..28999 (504 bp)
Type: Others
Protein ID: WP_172423981.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ERICV_RS2430519434..19676+243WP_172423962.1hypothetical protein-
ERICV_RS2431019694..20371+678WP_172423963.1N-acetylmuramoyl-L-alanine amidase-
ERICV_RS2431520378..20842+465WP_024094413.1hypothetical protein-
ERICV_RS2432020860..21135+276WP_036658889.1hypothetical protein-
ERICV_RS2432521148..21387+240WP_172423964.1transposase-
ERICV_RS2433021475..21744-270WP_172423965.1hypothetical protein-
ERICV_RS2433521784..22026-243WP_172423966.1hypothetical protein-
ERICV_RS2434022019..23002-984WP_172423967.1ParM/StbA family protein-
ERICV_RS2434523197..23487-291WP_172423968.1hypothetical protein-
ERICV_RS2435023514..23843-330WP_172423969.1type II toxin-antitoxin system PemK/MazF family toxinToxin
ERICV_RS2435523840..24079-240WP_172424007.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
ERICV_RS2436024651..25025-375WP_172423970.1hypothetical protein-
ERICV_RS2436525009..25197-189WP_172423971.1hypothetical protein-
ERICV_RS2437025384..25641-258WP_172423972.1hypothetical protein-
ERICV_RS2437525643..26026-384WP_172423973.1hypothetical protein-
ERICV_RS2438026033..26323-291WP_172423974.1hypothetical protein-
ERICV_RS2438526316..26639-324WP_172423975.1hypothetical protein-
ERICV_RS2439026672..26878-207WP_172423976.1hypothetical protein-
ERICV_RS2439526887..27585-699WP_172423977.1DNA cytosine methyltransferase-
ERICV_RS2440027592..27819-228WP_172423978.1hypothetical protein-
ERICV_RS2440528100..28300-201WP_172423979.1hypothetical protein-
ERICV_RS2441028303..28503-201WP_172423980.1hypothetical protein-
ERICV_RS2441528496..28999-504WP_172423981.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..4611446114


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-108)

Antitoxin

SpoVT-AbrB domain

(7-48)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12491.51 Da        Isoelectric Point: 8.0834

>T73217 WP_172423969.1 NZ_CP019718:c23843-23514 [Paenibacillus larvae subsp. larvae]
VTVIPDRGDIVYMDFNPQSGHEQAGWRPALVLSPKLFNATTNLAVVCPITSRVKNYLFEVHLPDTMKTKGVILVHQLKSA
DWRSRKLEIRERAPQEIIDEVIEKIHTFL

Download         Length: 330 bp

>T73217 NZ_CP019718:c23843-23514 [Paenibacillus larvae subsp. larvae]
GTGACAGTTATCCCAGATCGCGGTGATATTGTTTATATGGACTTTAATCCGCAAAGCGGGCATGAACAAGCTGGATGGCG
ACCAGCTCTTGTGTTATCGCCCAAATTATTTAATGCGACAACGAATCTTGCTGTAGTCTGCCCCATCACTTCACGGGTGA
AAAACTACTTATTTGAAGTTCATCTTCCAGACACTATGAAGACAAAAGGTGTTATACTTGTACACCAATTGAAAAGCGCC
GATTGGAGATCGCGGAAATTAGAAATTCGGGAGAGAGCACCACAAGAAATTATTGACGAAGTTATCGAAAAGATTCATAC
TTTCCTATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8980.29 Da        Isoelectric Point: 6.2179

>AT73217 WP_172424007.1 NZ_CP019718:c24079-23840 [Paenibacillus larvae subsp. larvae]
MSTLVSKWGNSLALRIPRHFAESLNLHEGTEVELKLSEDCLSVKPKKKRYTLEELCASIKDGNQHDLIDFGKPVGEEIW

Download         Length: 240 bp

>AT73217 NZ_CP019718:c24079-23840 [Paenibacillus larvae subsp. larvae]
ATGAGTACGCTTGTGAGCAAATGGGGAAATAGTCTGGCACTTCGTATTCCCAGACATTTTGCTGAAAGCTTGAATCTTCA
TGAAGGTACTGAAGTTGAATTAAAGCTATCAGAAGACTGCTTGAGTGTCAAGCCAAAGAAAAAAAGGTATACCCTTGAGG
AACTTTGTGCTTCTATTAAAGATGGCAATCAGCATGACCTTATTGACTTCGGTAAACCTGTTGGGGAGGAAATTTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References