Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3868939..3869534 Replicon chromosome
Accession NZ_CP019717
Organism Paenibacillus larvae subsp. larvae strain Eric_V

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ERICV_RS20100 Protein ID WP_023483433.1
Coordinates 3869241..3869534 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W2E434
Locus tag ERICV_RS20095 Protein ID WP_036658190.1
Coordinates 3868939..3869208 (+) Length 90 a.a.

Genomic Context

ERICV_RS20070ERICV_RS20075ERICV_RS20080ERICV_RS20095ERICV_RS20100ERICV_RS20105ERICV_RS20110ERICV_RS20115ERICV_RS20090
Location: 3864370..3865656 (1287 bp)
Type: Others
Protein ID: WP_036658196.1
Location: 3865953..3866402 (450 bp)
Type: Others
Protein ID: WP_172423637.1
Location: 3866374..3866538 (165 bp)
Type: Others
Protein ID: WP_172423638.1
Location: 3868939..3869208 (270 bp)
Type: Antitoxin
Protein ID: WP_036658190.1
Location: 3869241..3869534 (294 bp)
Type: Toxin
Protein ID: WP_023483433.1
Location: 3869786..3870076 (291 bp)
Type: Others
Protein ID: WP_023483432.1
Location: 3870073..3872583 (2511 bp)
Type: Others
Protein ID: WP_023483431.1
Location: 3872689..3872985 (297 bp)
Type: Others
Protein ID: WP_036658187.1
Location: 3868288..3868620 (333 bp)
Type: Others
Protein ID: WP_023483434.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ERICV_RS200703864370..3865656+1287WP_036658196.1MFS transporter-
ERICV_RS200753865953..3866402+450WP_172423637.1transposase-
ERICV_RS200803866374..3866538+165WP_172423638.1hypothetical protein-
ERICV_RS200903868288..3868620-333WP_023483434.1hypothetical protein-
ERICV_RS200953868939..3869208+270WP_036658190.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
ERICV_RS201003869241..3869534+294WP_023483433.1type II toxin-antitoxin system PemK/MazF family toxinToxin
ERICV_RS201053869786..3870076+291WP_023483432.1metalloregulator ArsR/SmtB family transcription factor-
ERICV_RS201103870073..3872583+2511WP_023483431.1FAD-dependent oxidoreductase-
ERICV_RS201153872689..3872985+297WP_036658187.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegrative and Conjugative Element--3844436..4062929218493
-flankIS/Tn--3867819..3868100281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-95)

Antitoxin

Antitoxin PemI-like

(11-89)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10996.71 Da        Isoelectric Point: 6.7162

>T73216 WP_023483433.1 NZ_CP019717:3869241-3869534 [Paenibacillus larvae subsp. larvae]
MDFNPQIGHEQAGRRPGLVVSPTSFNRVTGFIVVCPITRTVRNYPYEVPLPSDLMTEGVVLAHQVKSLDWKARKAEVREK
VPQEIIDDVLDLIHTFL

Download         Length: 294 bp

>T73216 NZ_CP019717:3869241-3869534 [Paenibacillus larvae subsp. larvae]
ATGGATTTTAACCCGCAGATTGGACATGAACAAGCCGGAAGAAGACCAGGCCTTGTTGTCTCTCCTACATCATTCAATAG
GGTAACAGGCTTTATAGTTGTATGCCCTATTACAAGAACCGTTAGGAATTATCCATATGAAGTTCCCCTCCCTTCCGATC
TTATGACCGAAGGTGTTGTTTTGGCTCATCAAGTAAAAAGCTTGGATTGGAAGGCAAGAAAGGCAGAAGTTCGGGAAAAA
GTACCACAAGAAATTATTGACGATGTACTGGATTTAATTCACACTTTCCTATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10006.46 Da        Isoelectric Point: 5.7379

>AT73216 WP_036658190.1 NZ_CP019717:3868939-3869208 [Paenibacillus larvae subsp. larvae]
MGKDRERMSVMSTIVSKWGNSLAIRIPSNLAESLNIKEGSEVELSIMDSTLTIKPKKRKPTLEELLAKITDGNHHEEIDF
GKPEGNEVW

Download         Length: 270 bp

>AT73216 NZ_CP019717:3868939-3869208 [Paenibacillus larvae subsp. larvae]
ATGGGTAAAGACAGGGAAAGGATGAGTGTAATGAGCACAATTGTGAGCAAATGGGGAAATAGTCTCGCAATCCGCATTCC
AAGTAACCTGGCAGAAAGCCTAAACATAAAAGAGGGTTCTGAAGTTGAATTAAGCATCATGGATAGTACACTAACTATAA
AACCTAAAAAACGTAAGCCAACTCTTGAAGAATTACTGGCAAAAATAACAGACGGTAACCATCATGAGGAAATTGACTTT
GGAAAACCGGAGGGGAACGAGGTTTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A2L1TQJ8

References