Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 234815..235410 Replicon chromosome
Accession NZ_CP019697
Organism Paenalcaligenes hominis strain microbial

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag PAEH1_RS01240 Protein ID WP_077733049.1
Coordinates 235105..235410 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag PAEH1_RS01235 Protein ID WP_077733048.1
Coordinates 234815..235108 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAEH1_RS01210 230009..230752 + 744 WP_077733043.1 type 1 glutamine amidotransferase -
PAEH1_RS01215 230754..231044 - 291 WP_077733044.1 hypothetical protein -
PAEH1_RS01220 231249..231722 - 474 WP_077733045.1 nuclear transport factor 2 family protein -
PAEH1_RS01225 231895..232815 + 921 WP_077733046.1 alpha/beta hydrolase -
PAEH1_RS13680 233092..233241 + 150 WP_173834767.1 hypothetical protein -
PAEH1_RS01230 233485..234708 + 1224 WP_173834768.1 MFS transporter -
PAEH1_RS01235 234815..235108 - 294 WP_077733048.1 putative addiction module antidote protein Antitoxin
PAEH1_RS01240 235105..235410 - 306 WP_077733049.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PAEH1_RS01245 235419..235895 + 477 WP_149026059.1 hypothetical protein -
PAEH1_RS01250 236384..237691 + 1308 WP_077733051.1 site-specific integrase -
PAEH1_RS01255 237654..237880 - 227 Protein_249 AlpA family phage regulatory protein -
PAEH1_RS01260 237877..238110 - 234 WP_077733052.1 hypothetical protein -
PAEH1_RS01270 238616..239509 - 894 WP_077733054.1 recombination-associated protein RdgC -
PAEH1_RS01275 239558..239788 - 231 WP_077733055.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 234815..299804 64989


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-84)

Antitoxin

Uncharacterized protein HI1420

(4-94)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11464.24 Da        Isoelectric Point: 10.6761

>T73196 WP_077733049.1 NZ_CP019697:c235410-235105 [Paenalcaligenes hominis]
MNTVNRTEKFSQWLTALKDVKAKAKIITRIRQASLGNFGDTKPLSDGVSEMRVHFGPGYRVYYAREGRTVYLLLSGGDKS
SQDKDIKSAIAMWKRIQKELP

Download         Length: 306 bp

>T73196 NZ_CP019697:c235410-235105 [Paenalcaligenes hominis]
ATGAACACAGTCAACAGAACGGAAAAATTCAGCCAATGGCTGACCGCTCTTAAAGATGTAAAGGCAAAAGCCAAAATAAT
CACTCGCATTAGGCAAGCGTCACTAGGCAATTTCGGCGATACCAAACCTCTAAGTGATGGCGTATCTGAAATGCGCGTTC
ATTTTGGCCCCGGCTACCGTGTGTACTACGCCCGTGAAGGCCGAACCGTTTACCTCTTGCTTAGCGGTGGCGATAAGTCT
AGTCAAGACAAAGACATCAAGTCAGCCATAGCAATGTGGAAACGAATCCAAAAGGAACTACCATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10188.61 Da        Isoelectric Point: 4.5859

>AT73196 WP_077733048.1 NZ_CP019697:c235108-234815 [Paenalcaligenes hominis]
MTTINTAPFDAAEYLDSEEAIAAYLSAALEEDDPALFLAALADVAKARGMTQMAKDAGVGRESLYKALAPGAKPRYDTVL
KLAKAAGVKFTVEPAHT

Download         Length: 294 bp

>AT73196 NZ_CP019697:c235108-234815 [Paenalcaligenes hominis]
ATGACAACGATTAATACCGCACCTTTCGATGCCGCTGAGTACCTAGACAGCGAAGAAGCTATTGCCGCTTACCTTTCTGC
CGCCCTAGAGGAAGATGATCCAGCGCTATTTTTAGCTGCCCTAGCTGATGTTGCCAAAGCTCGCGGCATGACTCAAATGG
CCAAAGACGCTGGCGTAGGCCGTGAAAGCCTATACAAGGCATTAGCCCCTGGCGCTAAGCCTCGCTATGACACCGTACTA
AAACTAGCTAAAGCGGCTGGGGTTAAGTTTACGGTTGAGCCCGCTCATACCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References