Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 234815..235410 Replicon chromosome
Accession NZ_CP019697
Organism Paenalcaligenes hominis strain microbial

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag PAEH1_RS01240 Protein ID WP_077733049.1
Coordinates 235105..235410 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag PAEH1_RS01235 Protein ID WP_077733048.1
Coordinates 234815..235108 (-) Length 98 a.a.

Genomic Context

PAEH1_RS01210PAEH1_RS01225PAEH1_RS13680PAEH1_RS01230PAEH1_RS01245PAEH1_RS01250PAEH1_RS01215PAEH1_RS01220PAEH1_RS01235PAEH1_RS01240PAEH1_RS01255PAEH1_RS01260PAEH1_RS01270PAEH1_RS01275
Location: 230009..230752 (744 bp)
Type: Others
Protein ID: WP_077733043.1
Location: 231895..232815 (921 bp)
Type: Others
Protein ID: WP_077733046.1
Location: 233092..233241 (150 bp)
Type: Others
Protein ID: WP_173834767.1
Location: 233485..234708 (1224 bp)
Type: Others
Protein ID: WP_173834768.1
Location: 235419..235895 (477 bp)
Type: Others
Protein ID: WP_149026059.1
Location: 236384..237691 (1308 bp)
Type: Others
Protein ID: WP_077733051.1
Location: 230754..231044 (291 bp)
Type: Others
Protein ID: WP_077733044.1
Location: 231249..231722 (474 bp)
Type: Others
Protein ID: WP_077733045.1
Location: 234815..235108 (294 bp)
Type: Antitoxin
Protein ID: WP_077733048.1
Location: 235105..235410 (306 bp)
Type: Toxin
Protein ID: WP_077733049.1
Location: 237654..237880 (227 bp)
Type: Others
Protein ID: Protein_249
Location: 237877..238110 (234 bp)
Type: Others
Protein ID: WP_077733052.1
Location: 238616..239509 (894 bp)
Type: Others
Protein ID: WP_077733054.1
Location: 239558..239788 (231 bp)
Type: Others
Protein ID: WP_077733055.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PAEH1_RS01210230009..230752+744WP_077733043.1type 1 glutamine amidotransferase-
PAEH1_RS01215230754..231044-291WP_077733044.1hypothetical protein-
PAEH1_RS01220231249..231722-474WP_077733045.1nuclear transport factor 2 family protein-
PAEH1_RS01225231895..232815+921WP_077733046.1alpha/beta hydrolase-
PAEH1_RS13680233092..233241+150WP_173834767.1hypothetical protein-
PAEH1_RS01230233485..234708+1224WP_173834768.1MFS transporter-
PAEH1_RS01235234815..235108-294WP_077733048.1putative addiction module antidote proteinAntitoxin
PAEH1_RS01240235105..235410-306WP_077733049.1type II toxin-antitoxin system RelE/ParE family toxinToxin
PAEH1_RS01245235419..235895+477WP_149026059.1hypothetical protein-
PAEH1_RS01250236384..237691+1308WP_077733051.1site-specific integrase-
PAEH1_RS01255237654..237880-227Protein_249AlpA family phage regulatory protein-
PAEH1_RS01260237877..238110-234WP_077733052.1hypothetical protein-
PAEH1_RS01270238616..239509-894WP_077733054.1recombination-associated protein RdgC-
PAEH1_RS01275239558..239788-231WP_077733055.1hypothetical protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--234815..29980464989


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-84)

Antitoxin

Uncharacterized protein HI1420

(4-94)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11464.24 Da        Isoelectric Point: 10.6761

>T73196 WP_077733049.1 NZ_CP019697:c235410-235105 [Paenalcaligenes hominis]
MNTVNRTEKFSQWLTALKDVKAKAKIITRIRQASLGNFGDTKPLSDGVSEMRVHFGPGYRVYYAREGRTVYLLLSGGDKS
SQDKDIKSAIAMWKRIQKELP

Download         Length: 306 bp

>T73196 NZ_CP019697:c235410-235105 [Paenalcaligenes hominis]
ATGAACACAGTCAACAGAACGGAAAAATTCAGCCAATGGCTGACCGCTCTTAAAGATGTAAAGGCAAAAGCCAAAATAAT
CACTCGCATTAGGCAAGCGTCACTAGGCAATTTCGGCGATACCAAACCTCTAAGTGATGGCGTATCTGAAATGCGCGTTC
ATTTTGGCCCCGGCTACCGTGTGTACTACGCCCGTGAAGGCCGAACCGTTTACCTCTTGCTTAGCGGTGGCGATAAGTCT
AGTCAAGACAAAGACATCAAGTCAGCCATAGCAATGTGGAAACGAATCCAAAAGGAACTACCATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10188.61 Da        Isoelectric Point: 4.5859

>AT73196 WP_077733048.1 NZ_CP019697:c235108-234815 [Paenalcaligenes hominis]
MTTINTAPFDAAEYLDSEEAIAAYLSAALEEDDPALFLAALADVAKARGMTQMAKDAGVGRESLYKALAPGAKPRYDTVL
KLAKAAGVKFTVEPAHT

Download         Length: 294 bp

>AT73196 NZ_CP019697:c235108-234815 [Paenalcaligenes hominis]
ATGACAACGATTAATACCGCACCTTTCGATGCCGCTGAGTACCTAGACAGCGAAGAAGCTATTGCCGCTTACCTTTCTGC
CGCCCTAGAGGAAGATGATCCAGCGCTATTTTTAGCTGCCCTAGCTGATGTTGCCAAAGCTCGCGGCATGACTCAAATGG
CCAAAGACGCTGGCGTAGGCCGTGAAAGCCTATACAAGGCATTAGCCCCTGGCGCTAAGCCTCGCTATGACACCGTACTA
AAACTAGCTAAAGCGGCTGGGGTTAAGTTTACGGTTGAGCCCGCTCATACCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
No matching records found

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References