Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 4419138..4419622 Replicon chromosome
Accession NZ_CP019689
Organism Shigella sonnei strain 75/02

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A377EAU1
Locus tag BZ172_RS24160 Protein ID WP_014334020.1
Coordinates 4419138..4419428 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A376K4R9
Locus tag BZ172_RS24165 Protein ID WP_005142544.1
Coordinates 4419428..4419622 (-) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZ172_RS24110 (4414380) 4414380..4414601 - 222 WP_000763356.1 TraR/DksA family transcriptional regulator -
BZ172_RS24115 (4414649) 4414649..4415272 - 624 WP_000211516.1 phage antirepressor Ant -
BZ172_RS24120 (4415540) 4415540..4415809 - 270 Protein_4316 antA/AntB antirepressor family protein -
BZ172_RS24130 (4416235) 4416235..4416339 - 105 Protein_4317 4Fe-4S binding protein -
BZ172_RS24135 (4416350) 4416350..4417426 - 1077 Protein_4318 molybdopterin dinucleotide binding domain-containing protein -
BZ172_RS24145 (4417484) 4417484..4418181 + 698 WP_094096600.1 IS1-like element IS1A family transposase -
BZ172_RS24150 (4418329) 4418329..4418694 - 366 WP_024174355.1 hypothetical protein -
BZ172_RS24155 (4418706) 4418706..4418858 - 153 WP_000379558.1 DUF1391 family protein -
BZ172_RS24160 (4419138) 4419138..4419428 - 291 WP_014334020.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BZ172_RS24165 (4419428) 4419428..4419622 - 195 WP_005142544.1 hypothetical protein Antitoxin
BZ172_RS24170 (4419642) 4419642..4420127 - 486 WP_053002468.1 helix-turn-helix domain-containing protein -
BZ172_RS24175 (4420254) 4420254..4420517 + 264 WP_001048456.1 helix-turn-helix transcriptional regulator -
BZ172_RS24180 (4420514) 4420514..4420939 + 426 WP_000693826.1 toxin YdaT family protein -
BZ172_RS24185 (4421011) 4421011..4422075 + 1065 WP_001262380.1 hypothetical protein -
BZ172_RS24190 (4422082) 4422082..4422828 + 747 WP_000788740.1 ATP-binding protein -
BZ172_RS24195 (4422850) 4422850..4423575 + 726 WP_000450631.1 DUF1627 domain-containing protein -
BZ172_RS24200 (4423591) 4423591..4424013 + 423 WP_001151171.1 DUF977 family protein -
BZ172_RS24205 (4424071) 4424071..4424427 + 357 WP_005140877.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - stxA / stxB 4354680..4428424 73744


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11062.93 Da        Isoelectric Point: 10.2013

>T73193 WP_014334020.1 NZ_CP019689:c4419428-4419138 [Shigella sonnei]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS

Download         Length: 291 bp

>T73193 NZ_CP019689:c4419428-4419138 [Shigella sonnei]
ATGTTACCCGTTTTATGGCTACCATCTGCTCGTGATGATTTGCGCCAGATCGTAGCCTACATAGCTAAAGAAAATCCCGC
GGCAGCACGCAGAATGAAAATTCGAATTGAAACATCCGTTTTGCCGCTCACAGAGCATCCTTACCTGTATCCTCCAAGCG
AGCGAGTTCTTGGTCTTCGTGAAATTGTAACTCATCCTAACTACATCATCCTTTACCGAGTAACAGCATCAAGCATAGAA
GTAGTAAATATTGTGCATTCTCGAAGACAGTATCCAGGCAAAAACAGTTAA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7097.98 Da        Isoelectric Point: 4.1759

>AT73193 WP_005142544.1 NZ_CP019689:c4419622-4419428 [Shigella sonnei]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE

Download         Length: 195 bp

>AT73193 NZ_CP019689:c4419622-4419428 [Shigella sonnei]
ATGAGTACAGTCCTTTCCCCAATGGTTTCAGAATTTGAGACAGTTGAGCAAGAAAATAGTTACAACGAATGGCTGCGGGC
CAAAGTAGCAGCAAGCCTCGCGGATCCCCGCCCGGCGATTCCGCATGATGAGGTAATGGCGGAAATGGAACAAATTATTG
CCCAAATTGCTGCTGCAACTCACAGAGGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377EAU1

Antitoxin

Source ID Structure
AlphaFold DB A0A376K4R9

References