Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3173963..3174581 Replicon chromosome
Accession NZ_CP019689
Organism Shigella sonnei strain 75/02

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag BZ172_RS17060 Protein ID WP_001291435.1
Coordinates 3173963..3174181 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H8V4S8
Locus tag BZ172_RS17065 Protein ID WP_000344804.1
Coordinates 3174207..3174581 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZ172_RS17025 (3169255) 3169255..3169827 + 573 WP_000779812.1 YbaY family lipoprotein -
BZ172_RS17030 (3169858) 3169858..3170169 - 312 WP_000409911.1 MGMT family protein -
BZ172_RS17040 (3170548) 3170548..3170901 + 354 WP_000878140.1 DUF1428 domain-containing protein -
BZ172_RS17045 (3170943) 3170943..3172491 - 1549 Protein_3060 cyclic-guanylate-specific phosphodiesterase PdeB -
BZ172_RS17050 (3172655) 3172655..3173125 - 471 WP_000136192.1 YlaC family protein -
BZ172_RS17055 (3173241) 3173241..3173792 - 552 WP_000102564.1 maltose O-acetyltransferase -
BZ172_RS17060 (3173963) 3173963..3174181 - 219 WP_001291435.1 HHA domain-containing protein Toxin
BZ172_RS17065 (3174207) 3174207..3174581 - 375 WP_000344804.1 Hha toxicity modulator TomB Antitoxin
BZ172_RS17070 (3175127) 3175127..3178276 - 3150 WP_001132464.1 efflux RND transporter permease AcrB -
BZ172_RS17075 (3178299) 3178299..3179492 - 1194 WP_011310152.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T73183 WP_001291435.1 NZ_CP019689:c3174181-3173963 [Shigella sonnei]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T73183 NZ_CP019689:c3174181-3173963 [Shigella sonnei]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14615.43 Da        Isoelectric Point: 4.6232

>AT73183 WP_000344804.1 NZ_CP019689:c3174581-3174207 [Shigella sonnei]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIETFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT73183 NZ_CP019689:c3174581-3174207 [Shigella sonnei]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGAGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H8V4S8

References