Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1087363..1088017 Replicon chromosome
Accession NZ_CP019689
Organism Shigella sonnei strain 75/02

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag BZ172_RS05795 Protein ID WP_000244777.1
Coordinates 1087363..1087770 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag BZ172_RS05800 Protein ID WP_000354046.1
Coordinates 1087751..1088017 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZ172_RS05775 (1083320) 1083320..1085053 - 1734 WP_000813167.1 single-stranded-DNA-specific exonuclease RecJ -
BZ172_RS05780 (1085059) 1085059..1085769 - 711 WP_000715206.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BZ172_RS05785 (1085794) 1085794..1086690 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
BZ172_RS05790 (1086802) 1086802..1087323 + 522 WP_001055874.1 flavodoxin FldB -
BZ172_RS05795 (1087363) 1087363..1087770 - 408 WP_000244777.1 protein YgfX Toxin
BZ172_RS05800 (1087751) 1087751..1088017 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
BZ172_RS05805 (1088260) 1088260..1089240 + 981 WP_000886060.1 tRNA-modifying protein YgfZ -
BZ172_RS05810 (1089436) 1089436..1090095 - 660 WP_000250274.1 hemolysin III family protein -
BZ172_RS05815 (1090259) 1090259..1090570 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
BZ172_RS05820 (1090615) 1090615..1092048 + 1434 WP_005137189.1 6-phospho-beta-glucosidase BglA -
BZ172_RS05825 (1092105) 1092105..1092848 - 744 WP_000951937.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T73178 WP_000244777.1 NZ_CP019689:c1087770-1087363 [Shigella sonnei]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T73178 NZ_CP019689:c1087770-1087363 [Shigella sonnei]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT73178 WP_000354046.1 NZ_CP019689:c1088017-1087751 [Shigella sonnei]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT73178 NZ_CP019689:c1088017-1087751 [Shigella sonnei]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References