Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel2-ATphRel2/DUF4065(antitoxin)
Location 2147629..2149076 Replicon chromosome
Accession NZ_CP019687
Organism Paenibacillus larvae subsp. larvae strain ATCC-9545

Toxin (Protein)


Gene name phRel2 Uniprot ID -
Locus tag BXP28_RS11195 Protein ID WP_046655328.1
Coordinates 2147629..2148324 (+) Length 232 a.a.

Antitoxin (Protein)


Gene name ATphRel2 Uniprot ID W2EHL1
Locus tag BXP28_RS11200 Protein ID WP_023483534.1
Coordinates 2148327..2149076 (+) Length 250 a.a.

Genomic Context

BXP28_RS11180BXP28_RS11195BXP28_RS11200BXP28_RS11205BXP28_RS11175BXP28_RS11185BXP28_RS11210BXP28_RS11215
Location: 2143623..2144846 (1224 bp)
Type: Others
Protein ID: WP_023483236.1
Location: 2147629..2148324 (696 bp)
Type: Toxin
Protein ID: WP_046655328.1
Location: 2148327..2149076 (750 bp)
Type: Antitoxin
Protein ID: WP_023483534.1
Location: 2149886..2150437 (552 bp)
Type: Others
Protein ID: WP_024094406.1
Location: 2142858..2143172 (315 bp)
Type: Others
Protein ID: WP_036654891.1
Location: 2145251..2146813 (1563 bp)
Type: Others
Protein ID: WP_036654894.1
Location: 2150639..2151121 (483 bp)
Type: Others
Protein ID: WP_024094407.1
Location: 2151370..2152437 (1068 bp)
Type: Others
Protein ID: WP_051428031.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BXP28_RS111752142858..2143172-315WP_036654891.1hypothetical protein-
BXP28_RS111802143623..2144846+1224WP_023483236.1IS256 family transposase-
BXP28_RS111852145251..2146813-1563WP_036654894.1M4 family metallopeptidase-
BXP28_RS111952147629..2148324+696WP_046655328.1hypothetical proteinToxin
BXP28_RS112002148327..2149076+750WP_023483534.1DUF4065 domain-containing proteinAntitoxin
BXP28_RS112052149886..2150437+552WP_024094406.1hypothetical protein-
BXP28_RS112102150639..2151121-483WP_024094407.1SocA family protein-
BXP28_RS112152151370..2152437-1068WP_051428031.1XRE family transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--2143623..21448461223


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(99-206)

Antitoxin

Antitoxin SocA-like, Panacea domain

(113-225)


Sequences

Toxin        


Download         Length: 232 a.a.        Molecular weight: 27728.80 Da        Isoelectric Point: 8.5708

>T73172 WP_046655328.1 NZ_CP019687:2147629-2148324 [Paenibacillus larvae subsp. larvae]
MDFSQRLGTIISIDYKPIIHLITEISDIHGEFSNEYLKECRNRLINMKKQLVRDTFEDGLNIVKEDFYSLVQNYHEMLRA
FIVETELEYDYADLHLRMRVKQMESIMHKLIFYKTGKKEEGKVPINKCLNDLLGIRILIGGFDYNCNKFNDLYQKIKSTH
KIKIENRSIEGYRGTHIYFYVNNQAFPWELQIWNKAHEKENEQLHKTHKSKREYIKWPNTYKNSKEHEGGV

Download         Length: 696 bp

>T73172 NZ_CP019687:2147629-2148324 [Paenibacillus larvae subsp. larvae]
ATGGATTTCAGTCAGCGGTTAGGAACTATTATAAGCATTGATTACAAACCTATAATACACTTGATAACTGAAATTAGTGA
TATACATGGAGAATTCTCAAATGAATATTTAAAAGAATGTAGAAACCGGTTAATAAATATGAAGAAACAGTTGGTTAGGG
ATACCTTTGAAGATGGACTTAATATTGTCAAAGAGGATTTTTATTCTTTAGTCCAAAATTATCATGAGATGCTTAGAGCC
TTCATTGTTGAAACTGAATTGGAATATGATTATGCCGATTTGCATTTGCGCATGAGAGTGAAACAAATGGAATCAATAAT
GCATAAATTGATTTTTTATAAGACAGGAAAAAAAGAGGAAGGGAAAGTTCCAATAAACAAGTGTTTGAATGATTTATTGG
GAATCAGAATATTAATTGGCGGATTTGACTACAATTGTAATAAATTCAATGACTTGTATCAAAAAATAAAGTCGACTCAT
AAAATAAAAATAGAAAATAGATCCATTGAGGGTTATCGAGGTACTCATATTTATTTTTATGTTAATAATCAAGCTTTTCC
TTGGGAACTTCAAATATGGAATAAAGCGCATGAGAAGGAAAATGAACAATTACATAAAACACATAAAAGTAAACGCGAGT
ACATAAAATGGCCTAATACATATAAAAATTCAAAAGAACATGAAGGAGGTGTTTGA

Antitoxin


Download         Length: 250 a.a.        Molecular weight: 28969.38 Da        Isoelectric Point: 6.9799

>AT73172 WP_023483534.1 NZ_CP019687:2148327-2149076 [Paenibacillus larvae subsp. larvae]
MAFHFVAIMSNYVKGMRIGWHYASEGKLDKALIKQFMSRVEEKYSDAQLGIHKIATDSVTWRSVVEKDSFFEDVFVTTDI
EKFVRLIAEDQELKAYDVAKFIVSTVQVSHLKLQKLLYYVYADFLLATGKKLFKEPIVAFEYGPVVEEVFHKYKVHGSSE
IDYKEDEYFCIYTDEFAVTPSFMRVASSEHGIYAVGFILKVLDKYESYSAGELVKKTHQVGGPWKRVYVKGMNYEITDEL
IKRYHKFVQ

Download         Length: 750 bp

>AT73172 NZ_CP019687:2148327-2149076 [Paenibacillus larvae subsp. larvae]
ATGGCATTTCACTTTGTAGCAATAATGAGTAACTATGTAAAAGGAATGCGTATCGGCTGGCATTATGCTTCAGAGGGGAA
ACTTGACAAAGCTTTGATAAAGCAATTTATGAGTAGAGTCGAGGAAAAATATAGTGATGCTCAATTAGGCATTCACAAAA
TTGCTACAGATTCTGTTACTTGGCGATCAGTCGTAGAAAAAGATTCATTTTTCGAGGATGTTTTTGTAACGACTGATATA
GAAAAATTTGTTAGGCTTATAGCAGAAGATCAGGAATTAAAGGCCTATGATGTAGCTAAATTTATAGTATCCACTGTACA
AGTATCACATTTAAAATTGCAGAAGCTGTTATACTATGTATATGCAGATTTTTTACTGGCTACAGGCAAAAAGTTATTCA
AAGAACCAATTGTAGCATTTGAATACGGCCCAGTGGTAGAAGAGGTTTTTCATAAATATAAGGTTCATGGTTCTTCTGAA
ATTGATTATAAAGAAGATGAGTATTTTTGTATTTATACGGATGAATTCGCCGTTACACCTTCTTTCATGAGAGTAGCATC
TTCTGAGCATGGTATTTATGCGGTTGGATTCATATTAAAGGTCCTAGATAAATACGAGTCATATTCAGCAGGAGAACTTG
TTAAAAAAACACATCAAGTAGGAGGCCCTTGGAAAAGGGTTTATGTAAAAGGAATGAATTATGAAATTACGGATGAATTG
ATCAAGAGATACCATAAATTTGTTCAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBW2EHL1

References