Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-UPF0150
Location 582484..583134 Replicon chromosome
Accession NZ_CP019687
Organism Paenibacillus larvae subsp. larvae strain ATCC-9545

Toxin (Protein)


Gene name hicA Uniprot ID W2E3Q1
Locus tag BXP28_RS03255 Protein ID WP_036658634.1
Coordinates 582931..583134 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID W2E4D8
Locus tag BXP28_RS03250 Protein ID WP_023484796.1
Coordinates 582484..582900 (-) Length 139 a.a.

Genomic Context

BXP28_RS03200BXP28_RS03205BXP28_RS03210BXP28_RS03215BXP28_RS03220BXP28_RS03225BXP28_RS03230BXP28_RS03235BXP28_RS22435BXP28_RS03240BXP28_RS03245BXP28_RS03260BXP28_RS03265BXP28_RS03270BXP28_RS03275BXP28_RS03280BXP28_RS03285BXP28_RS03250BXP28_RS03255
Location: 577622..578434 (813 bp)
Type: Others
Protein ID: WP_104932619.1
Location: 578553..578771 (219 bp)
Type: Others
Protein ID: WP_036658649.1
Location: 578764..579138 (375 bp)
Type: Others
Protein ID: WP_036658646.1
Location: 579320..579685 (366 bp)
Type: Others
Protein ID: WP_036658643.1
Location: 579702..580484 (783 bp)
Type: Others
Protein ID: WP_023483250.1
Location: 580468..580650 (183 bp)
Type: Others
Protein ID: WP_036658642.1
Location: 580702..580935 (234 bp)
Type: Others
Protein ID: WP_036658640.1
Location: 580928..581173 (246 bp)
Type: Others
Protein ID: WP_036658638.1
Location: 581170..581313 (144 bp)
Type: Others
Protein ID: WP_155116353.1
Location: 581442..581879 (438 bp)
Type: Others
Protein ID: WP_077584885.1
Location: 582085..582429 (345 bp)
Type: Others
Protein ID: WP_036658635.1
Location: 583314..583628 (315 bp)
Type: Others
Protein ID: WP_023484126.1
Location: 583615..583959 (345 bp)
Type: Others
Protein ID: WP_077584886.1
Location: 584063..584377 (315 bp)
Type: Others
Protein ID: WP_023484127.1
Location: 584358..586082 (1725 bp)
Type: Others
Protein ID: WP_077584887.1
Location: 586097..587332 (1236 bp)
Type: Others
Protein ID: WP_036656297.1
Location: 587322..588038 (717 bp)
Type: Others
Protein ID: WP_046655269.1
Location: 582484..582900 (417 bp)
Type: Antitoxin
Protein ID: WP_023484796.1
Location: 582931..583134 (204 bp)
Type: Toxin
Protein ID: WP_036658634.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BXP28_RS03200577622..578434+813WP_104932619.1ATP-binding protein-
BXP28_RS03205578553..578771+219WP_036658649.1hypothetical protein-
BXP28_RS03210578764..579138+375WP_036658646.1RusA family crossover junction endodeoxyribonuclease-
BXP28_RS03215579320..579685+366WP_036658643.1hypothetical protein-
BXP28_RS03220579702..580484+783WP_023483250.1DNA cytosine methyltransferase-
BXP28_RS03225580468..580650+183WP_036658642.1hypothetical protein-
BXP28_RS03230580702..580935+234WP_036658640.1hypothetical protein-
BXP28_RS03235580928..581173+246WP_036658638.1hypothetical protein-
BXP28_RS22435581170..581313+144WP_155116353.1hypothetical protein-
BXP28_RS03240581442..581879+438WP_077584885.1transcriptional regulator-
BXP28_RS03245582085..582429+345WP_036658635.1YxeA family protein-
BXP28_RS03250582484..582900-417WP_023484796.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
BXP28_RS03255582931..583134-204WP_036658634.1type II toxin-antitoxin system HicA family toxinToxin
BXP28_RS03260583314..583628+315WP_023484126.1hypothetical protein-
BXP28_RS03265583615..583959+345WP_077584886.1HNH endonuclease-
BXP28_RS03270584063..584377+315WP_023484127.1P27 family phage terminase small subunit-
BXP28_RS03275584358..586082+1725WP_077584887.1terminase large subunit-
BXP28_RS03280586097..587332+1236WP_036656297.1phage portal protein-
BXP28_RS03285587322..588038+717WP_046655269.1Clp protease ClpP-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--567632..60888741255


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-66)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-107)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 7803.12 Da        Isoelectric Point: 10.9763

>T73170 WP_036658634.1 NZ_CP019687:c583134-582931 [Paenibacillus larvae subsp. larvae]
MINLTKAYSSREVIKILREDGWIHKNTEGDHWHFIHPTKKGKVTVPHPKKGLKRRTTKSIFEQAGLI

Download         Length: 204 bp

>T73170 NZ_CP019687:c583134-582931 [Paenibacillus larvae subsp. larvae]
ATGATAAACCTCACCAAAGCATACTCATCAAGAGAGGTTATCAAAATCTTAAGAGAGGATGGCTGGATACATAAAAACAC
CGAAGGCGATCATTGGCACTTCATACACCCTACTAAAAAAGGAAAGGTGACTGTACCCCATCCGAAAAAAGGCTTGAAAC
GCCGAACAACAAAAAGTATCTTTGAGCAGGCAGGGCTTATATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15378.23 Da        Isoelectric Point: 4.1262

>AT73170 WP_023484796.1 NZ_CP019687:c582900-582484 [Paenibacillus larvae subsp. larvae]
MKYIYPAVFSPGEPDEGGFTVTFPDLPGCISEGDDLEEALRMAKDALGGHLYLMEEDGDEIPRPSQPDSIQLETGEFVSL
IQANTNFVRERIRNKAVNKTLTIPKWLNDAATEEGINFSQTLQDALKQKLDIKVNDFS

Download         Length: 417 bp

>AT73170 NZ_CP019687:c582900-582484 [Paenibacillus larvae subsp. larvae]
ATGAAGTACATTTACCCTGCTGTTTTTAGTCCTGGCGAACCAGACGAAGGAGGCTTTACTGTCACATTCCCTGACTTGCC
AGGCTGCATATCTGAAGGCGATGATCTGGAAGAAGCCCTGCGCATGGCAAAGGACGCTTTAGGCGGCCACCTCTATCTGA
TGGAAGAGGACGGCGACGAAATACCGCGGCCGTCACAACCAGACTCTATACAGCTTGAAACTGGAGAATTCGTTTCTCTA
ATTCAGGCTAATACCAACTTTGTCCGGGAGCGGATTAGAAACAAGGCTGTGAACAAAACGCTTACCATCCCAAAATGGCT
TAATGATGCAGCAACTGAGGAAGGAATAAACTTTTCTCAGACGCTCCAGGATGCACTAAAACAAAAACTTGATATCAAAG
TAAATGACTTCTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBW2E3Q1

Antitoxin

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Source
ID
Structure
AlphaFold DBW2E4D8

References