Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3178722..3180469 Replicon chromosome
Accession NZ_CP019686
Organism Proteus sp. CD3

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag BTA34_RS14210 Protein ID WP_151436126.1
Coordinates 3178722..3180095 (+) Length 458 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag BTA34_RS14215 Protein ID WP_151436127.1
Coordinates 3180092..3180469 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTA34_RS14195 (BTA34_14215) 3174398..3175366 - 969 WP_109374283.1 ABC transporter permease -
BTA34_RS14200 (BTA34_14220) 3175366..3176949 - 1584 WP_151436124.1 ABC transporter substrate-binding protein -
BTA34_RS14205 (BTA34_14225) 3177354..3178343 - 990 WP_151436125.1 glycosyltransferase -
BTA34_RS14210 (BTA34_14230) 3178722..3180095 + 1374 WP_151436126.1 HipA domain-containing protein Toxin
BTA34_RS14215 (BTA34_14235) 3180092..3180469 + 378 WP_151436127.1 helix-turn-helix transcriptional regulator Antitoxin
BTA34_RS14220 (BTA34_14240) 3180598..3181101 - 504 WP_151436128.1 hydrogenase maturation peptidase HycI -
BTA34_RS14225 (BTA34_14245) 3181098..3181508 - 411 WP_151436129.1 formate hydrogenlyase maturation HycH family protein -
BTA34_RS14230 (BTA34_14250) 3181501..3182283 - 783 WP_151436130.1 NADH-quinone oxidoreductase subunit B family protein -
BTA34_RS14235 (BTA34_14255) 3182280..3182834 - 555 WP_151436131.1 hydrogenase 4 subunit H -
BTA34_RS14240 (BTA34_14260) 3182846..3184579 - 1734 WP_151436132.1 hydrogenase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(174-415)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-103)


Sequences

Toxin        


Download         Length: 458 a.a.        Molecular weight: 52528.15 Da        Isoelectric Point: 4.7736

>T73167 WP_151436126.1 NZ_CP019686:3178722-3180095 [Proteus sp. CD3]
MEKVTLQAFLDQEWRDIAIINFPDHDRALYASKYDITYPITELEYETNYSVDYLYQDDNHSVSINHPVALYFDDNGSPGW
LKFLDDIVPSGASRRYWIQYLDISGLTVEQQNYELLYRGTISPIGNLRVKESLPAPSNLSEHLVFTIDDVKNRASDFLDY
AQRKGAAAGGATGAGGEAPKLLLRCSDNEEVWIDTYQDDVSNHDKYYLVKFPRGNRSSIDCDILRAEYHFYHELTSMGFN
TISIEGMRLEEGNNYPSLWLPRFDIKKENHKVIRLAMESVYSMLNKAPGTTLYHEIVIRELIDKINQSNMVTQFGFQFDI
SNFIIEWVRRDLLNIIFGNSDNHGRNTSFIRNNNTIYLAPIYDFAPMKADPEGIARTTKWHSQSEMGGEYNFINIANSLS
DLIPPEQLLNALKETALQLITLKERLEVRGVPTQILTMPSFGFDFISNKLERWGLLS

Download         Length: 1374 bp

>T73167 NZ_CP019686:3178722-3180095 [Proteus sp. CD3]
ATGGAAAAAGTAACATTACAAGCATTTCTTGATCAAGAATGGAGAGATATTGCTATTATTAATTTTCCTGATCATGATCG
CGCATTATATGCAAGCAAGTATGATATTACCTATCCAATCACTGAATTAGAGTATGAAACAAACTATTCAGTGGATTACC
TGTATCAAGATGACAACCACTCTGTTTCTATTAATCATCCTGTTGCCCTTTATTTTGATGATAATGGTTCACCAGGTTGG
CTTAAATTTTTAGATGATATTGTGCCTAGCGGTGCAAGTCGGAGATATTGGATCCAATATCTTGATATTTCGGGTTTGAC
TGTAGAACAACAAAACTATGAATTGCTTTATCGTGGTACTATTTCACCTATTGGTAATTTACGAGTAAAAGAATCATTGC
CAGCACCTTCTAACTTAAGCGAACATCTTGTTTTTACTATCGATGATGTCAAAAATAGAGCCAGCGATTTTCTAGATTAT
GCACAACGTAAAGGTGCTGCTGCTGGTGGTGCAACAGGGGCTGGAGGTGAAGCTCCGAAATTGTTATTAAGATGCAGTGA
TAATGAAGAAGTTTGGATTGATACTTATCAAGATGATGTCTCTAATCACGATAAATATTACTTAGTTAAATTTCCAAGAG
GAAATCGTTCAAGTATAGATTGTGATATTTTAAGAGCAGAATATCATTTTTATCACGAGCTTACTTCAATGGGCTTTAAT
ACTATTTCTATTGAAGGTATGCGCCTAGAGGAAGGAAATAATTACCCTTCTTTATGGCTTCCTCGTTTTGATATAAAAAA
AGAAAACCATAAAGTTATTCGTTTAGCTATGGAATCTGTCTATTCCATGTTGAATAAAGCACCAGGCACAACGCTATATC
ATGAAATAGTAATCAGAGAATTAATTGATAAAATTAATCAAAGCAATATGGTTACTCAATTTGGTTTTCAATTTGATATA
AGTAATTTTATTATTGAATGGGTAAGGCGAGATTTATTAAACATCATTTTTGGTAATAGCGATAACCATGGTCGAAATAC
TTCGTTTATAAGAAACAATAATACAATTTATCTTGCCCCTATCTATGACTTTGCACCGATGAAGGCTGATCCTGAAGGTA
TTGCTAGAACAACAAAATGGCATTCACAAAGTGAAATGGGTGGAGAGTACAATTTTATTAATATCGCAAATTCTTTATCT
GATTTAATTCCACCAGAACAACTACTCAACGCGTTAAAAGAAACTGCCTTACAACTTATTACGCTAAAAGAGAGATTAGA
GGTAAGAGGTGTGCCAACACAAATCCTCACAATGCCTTCATTTGGTTTTGATTTTATATCTAATAAGCTAGAACGCTGGG
GATTATTATCATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14162.48 Da        Isoelectric Point: 10.6253

>AT73167 WP_151436127.1 NZ_CP019686:3180092-3180469 [Proteus sp. CD3]
MSNVKNKIQINQSPARASKTRQSVATVDRKEVINQIMSQLLFGEISQGEALKMLRIKVLGLNQERYAKLINISRKTLSEI
ENDKGNYSADIVNKAFKPFGLKIGLIPFSPHVLFSLLKEYNNKNE

Download         Length: 378 bp

>AT73167 NZ_CP019686:3180092-3180469 [Proteus sp. CD3]
ATGAGTAATGTCAAAAATAAAATTCAAATAAACCAATCTCCAGCGAGAGCATCAAAAACACGCCAATCTGTTGCAACAGT
AGATAGAAAAGAAGTGATTAACCAGATAATGTCTCAGTTGTTATTTGGAGAAATAAGCCAAGGAGAGGCATTAAAAATGT
TAAGAATAAAAGTATTAGGTTTGAATCAAGAACGCTATGCAAAGCTTATTAATATCTCACGCAAGACACTATCAGAAATA
GAAAATGACAAAGGTAATTATTCTGCTGATATTGTTAATAAAGCATTTAAACCATTTGGATTAAAGATTGGGCTAATTCC
TTTTTCTCCTCATGTTTTATTTTCATTACTAAAAGAGTACAACAATAAAAATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References