Detailed information of TA system TA073155

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1686258..1686897
• Replicon: chromosome
• Accession: NZ_CP019672
• Organism: Burkholderia cenocepacia strain VC12308

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: A8E75_RS07765
• Protein ID: WP_171984140.1
• Coordinates: 1686258..1686674 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A364H554
• Locus tag: A8E75_RS07770
• Protein ID: WP_006481537.1
• Coordinates: 1686661..1686897 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A8E75_RS07740	1681365..1682465	-	1101	WP_034202287.1	nitronate monooxygenase	-
A8E75_RS07745	1682462..1683382	-	921	WP_077189417.1	enoyl-CoA hydratase	-
A8E75_RS07750	1683391..1684188	-	798	WP_006481539.1	hypothetical protein	-
A8E75_RS07755	1684199..1685092	-	894	WP_034202286.1	CoA transferase subunit A	-
A8E75_RS07760	1685102..1685998	-	897	WP_077189416.1	VOC family protein	-
A8E75_RS07765	1686258..1686674	-	417	WP_171984140.1	type II toxin-antitoxin system VapC family toxin	Toxin
A8E75_RS07770	1686661..1686897	-	237	WP_006481537.1	DNA-binding protein	Antitoxin
A8E75_RS07775	1687390..1688616	+	1227	WP_034202283.1	acyltransferase	-
A8E75_RS07780	1688627..1689304	-	678	WP_077189436.1	hypothetical protein	-
A8E75_RS07790	1689953..1690726	-	774	WP_077189415.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-130)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15388.61 Da
• Isoelectric Point: 6.8818

>T73155 WP_171984140.1 NZ_CP019672:c1686674-1686258 [Burkholderia cenocepacia]
VFLIDSNVISEIRKGKRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHSQASALEAWLTMILSGYAPNI
LPVDVETGQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVDDFARTGVRLLNPFE

Nucleotide

• Length: 417 bp

>T73155 NZ_CP019672:c1686674-1686258 [Burkholderia cenocepacia]
GTGTTTTTGATTGATTCGAACGTCATCAGCGAAATCAGGAAGGGCAAGCGAACCAACCGCGGCGTGCGGGCGTTCTTCAG
GCAGGCCGAAGCCGACGCGAGCCCGCTTTACCTGTCCGTCGTGACGGTGGCCGAGCTGCGGCGCGGTGTCGACCTGATCC
GTCATCGCGGCGATCACAGCCAGGCGTCGGCGCTCGAGGCCTGGCTGACGATGATCCTGTCCGGCTATGCGCCGAACATC
CTGCCGGTCGATGTCGAAACCGGCCAGATGTGGGGGCATTTGCGCGTGCCCGATCCGACGCACGAACTCGACAAGCTGAT
CGCGGCCACCGCATTGATCAACGATTTGACGGTCGTCACGCGCAACGTCGACGATTTCGCTCGCACCGGCGTCCGGTTGC
TGAATCCGTTCGAGTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8710.78 Da
• Isoelectric Point: 5.0916

>AT73155 WP_006481537.1 NZ_CP019672:c1686897-1686661 [Burkholderia cenocepacia]
MANLLVRNVDDTLVQSLREQAAANGRSAEAEHRAILAEALGRPKRRTFAQVLMSMPEVGEDADFQRVQDSGEVRRVFD

Nucleotide

• Length: 237 bp

>AT73155 NZ_CP019672:c1686897-1686661 [Burkholderia cenocepacia]
ATGGCAAATCTTCTGGTGCGTAACGTGGATGACACTCTCGTTCAAAGCCTGCGCGAGCAGGCTGCGGCCAACGGCAGGAG
CGCCGAGGCCGAACATCGAGCCATTCTGGCCGAAGCGCTCGGCCGGCCGAAGCGGCGCACATTCGCGCAAGTGCTGATGA
GCATGCCGGAGGTGGGCGAAGACGCGGATTTCCAACGTGTTCAGGATTCAGGCGAGGTCAGGCGTGTTTTTGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A364H554